ZIZYPHUS: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Zizyphus (Ziziphus jujuba) is a thorny shrub. The fruit is edible and looks similar to a date. It's rich in fiber, vitamin C, B vitamins, and fatty acids.

Zizyphus contains chemicals that might lower sugar and fat levels in the blood, and also cause sleepiness.

People use zizyphus for constipation, diabetes, aging skin, high cholesterol, insomnia, and many other conditions, but there is no good scientific evidence to support these uses.

Uses & Effectiveness ?

We currently have no information for ZIZYPHUS overview.

Side Effects

Special Precautions and Warnings

When taken by mouth: Zizyphus fruit is commonly consumed in foods. Zizyphus fruit or seed is possibly safe when used as medicine, short-term.

When applied to the skin: There isn't enough reliable information to know if zizyphus is safe or what the side effects might be. Pregnancy and breast-feeding: Zizyphus fruit is commonly consumed in foods. There isn't enough reliable information to know if zizyphus is safe to use as medicine when pregnant or breast-feeding. Stay on the safe side and stick to food amounts.

Latex allergy: People who are allergic to latex might also be allergic to zizyphus.

Surgery: Zizyphus might lower blood sugar and interfere with blood sugar control during and after surgery. Zizyphus might also slow down the central nervous system. Stop taking zizyphus at least 2 weeks before a scheduled surgery.

Interactions ?

Moderate Interaction

Be cautious with this combination

Medications for diabetes (Antidiabetes drugs) interacts with ZIZYPHUS
Zizyphus might lower blood sugar levels. Taking zizyphus along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.
Sedative medications (CNS depressants) interacts with ZIZYPHUS
Zizyphus might cause sleepiness and slowed breathing. Some medications, called sedatives, can also cause sleepiness and slowed breathing. Taking zizyphus with sedative medications might cause breathing problems and/or too much sleepiness.
Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with ZIZYPHUS
Some medications are changed and broken down by the liver. Zizyphus might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.

Dosing

Zizyphus fruit is commonly eaten as a food.

As medicine, zizyphus fruit extract and powder, as well as the seed extract, have been taken by mouth by adults in varying doses. Speak with a healthcare provider to find out what dose might be best for a specific condition.

View References

REFERENCES:

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Adzu, B., Amos, S., Dzarma, S., Wambebe, C., and Gamaniel, K. Effect of Zizyphus spina-christi Willd aqueous extract on the central nervous system in mice. J Ethnopharmacol. 2002;79(1):13-16. View abstract.

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Huang, X., Kojima-Yuasa, A., Xu, S., Norikura, T., Kennedy, D. O., Hasuma, T., and Matsui-Yuasa, I. Green tea extract enhances the selective cytotoxic activity of Zizyphus jujuba extracts in HepG2 cells. Am J Chin Med 2008;36(4):729-744. View abstract.

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Matsuda, H., Murakami, T., Ikebata, A., Yamahara, J., and Yoshikawa, M. Bioactive saponins and glycosides. XIV. Structure elucidation and immunological adjuvant activity of novel protojujubogenin type triterpene bisdesmosides, protojujubosides A, B, and B1, from the seeds of Zizyphus jujuba var. spinosa (Zizyphi Spinosi Semen). Chem Pharm Bull (Tokyo) 1999;47(12):1744-1748. View abstract.

Morishita, S., Mishima, Y., Hirai, Y., Saito, T., and Shoji, M. Pharmacological studies of water extract of the Zizyphus seed and the Zizyphus seed containing drug. Gen Pharmacol 1987;18(6):637-641. View abstract.

Nesseem, D. I., Michel, C. G., Sleem, A. A., and El-Alfy, T. S. Formulation and evaluation of antihyperglycemic leaf extracts of Zizyphus spina-christi (L.) Willd. Pharmazie 2009;64(2):104-109. View abstract.

Park, J. H., Lee, H. J., Koh, S. B., Ban, J. Y., and Seong, Y. H. Protection of NMDA-induced neuronal cell damage by methanol extract of zizyphi spinosi semen in cultured rat cerebellar granule cells. J Ethnopharmacol. 2004;95(1):39-45. View abstract.

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Shen, X., Tang, Y., Yang, R., Yu, L., Fang, T., and Duan, J. A. The protective effect of Zizyphus jujube fruit on carbon tetrachloride-induced hepatic injury in mice by anti-oxidative activities. J Ethnopharmacol. 4-21-2009;122(3):555-560. View abstract.

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Watanabe, I., Saito, H., and Takagi, K. Pharmacological studies of Zizyphus seeds. Jpn J Pharmacol 1973;23(4):563-571. View abstract.

Wu, S. X., Zhang, J. X., Xu, T., Li, L. F., Zhao, S. Y., and Lan, M. Y. [Effects of seeds, leaves and fruits of Ziziphus spinosa and jujuboside A on central nervous system function]. Zhongguo Zhong Yao Za Zhi 1993;18(11):685-4. View abstract.

Yoo, K. Y., Li, H., Hwang, I. K., Choi, J. H., Lee, C. H., Kwon, D. Y., Ryu, S. Y., Kim, Y. S., Kang, I. J., Shin, H. C., and Won, M. H. Zizyphus attenuates ischemic damage in the gerbil hippocampus via its antioxidant effect. J Med Food 2010;13(3):557-563. View abstract.

Yoshikawa, M., Murakami, T., Ikebata, A., Wakao, S., Murakami, N., Matsuda, H., and Yamahara, J. Bioactive saponins and glycosides. X. On the constituents of zizyphi spinosi semen, the seeds of Zizyphus jujuba Mill. var. spinosa Hu (1): structures and histamine release-inhibitory effect of jujubosides A1 and C and acetyljujuboside B. Chem Pharm Bull (Tokyo) 1997;45(7):1186-1192. View abstract.

Zhang, M., Ning, G., Shou, C., Lu, Y., Hong, D., and Zheng, X. Inhibitory effect of jujuboside A on glutamate-mediated excitatory signal pathway in hippocampus. Planta Med 2003;69(8):692-695. View abstract.

Ebrahimimd S, Ashkani-Esfahani S, Poormahmudibs A. Investigating the efficacy of zizyphus jujuba on neonatal jaundice. Iran J Pediatr. 2011 Sep;21(3):320-4. View abstract.

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Hajhashemi V, Safaei A. Hypnotic effect of Coriandrum sativum, Ziziphus jujuba, Lavandula angustifolia and Melissa officinalis extracts in mice. Res Pharm Sci. 2015 Nov-Dec;10(6):477-84. View abstract.

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Jing XY, Peng YR, Wang XM, Duan JA. Effects of Ziziphus jujuba fruit extracts on cytochrome P450 (CYP1A2) activity in rats. Chin J Nat Med. 2015 Aug;13(8):588-94. View abstract.

Kandimalla R, Dash S, Kalita S, Choudhury B, Malampati S, Kalita K, Kalita B, Devi R, Kotoky J. Protective Effect of Bioactivity Guided Fractions of Ziziphus jujuba Mill. Root Bark against Hepatic Injury and Chronic Inflammation via Inhibiting Inflammatory Markers and Oxidative Stress. Front Pharmacol. 2016 Sep7;7:298. View abstract.

Kim MJ, Jung JE, Lee S, Cho EJ, Kim HY. Effects of the fermented Zizyphus jujuba in the amyloid ß(25-35)-induced Alzheimer's disease mouse model. Nutr Res Pract 2021;15(2):173-86. View abstract.

Koohi-Hosseinabadi O, Andisheh-Tadbir A, Bahadori P, Sepehrimanesh M, Mardani M, Tanideh N. Comparison of the therapeutic effects of the dietary and topical forms of Zizyphus jujuba extract on oral mucositis induced by 5-fluorouracil: A golden hamster model. J Clin Exp Dent. 2015 Apr 1;7(2):e304-9. View abstract.

Lombardi C, Mistrello G, Roncarolo D, Senna G, Passalacqua G. Latex-jujube cross-reactivity: case report and immunological study. Allergy. 2005 Jul;60(7):971-2. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.

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ZIZYPHUS - Uses, Side Effects, and More

Overview

Uses & Effectiveness ?

Side Effects

Special Precautions and Warnings

Interactions ?

Moderate Interaction

Medications for diabetes (Antidiabetes drugs) interacts with ZIZYPHUS

Sedative medications (CNS depressants) interacts with ZIZYPHUS

Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with ZIZYPHUS

Dosing

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ZIZYPHUS - Uses, Side Effects, and More

Overview

Uses & Effectiveness ?

Side Effects

Special Precautions and Warnings

Interactions ?

Moderate Interaction

Medications for diabetes (Antidiabetes drugs) interacts with ZIZYPHUS

Sedative medications (CNS depressants) interacts with ZIZYPHUS

Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with ZIZYPHUS

Dosing

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