GREATER CELANDINE Overview Information
Greater celandine is a plant. The dried above-ground parts, root, and rhizome (underground stem) are used to make medicine. Don’t confuse greater celandine with lesser celandine (Family: Ranunculus ficaria).
Greater celandine is used for various problems with the digestive tract including upset stomach, gastroenteritis, irritable bowel syndrome (IBS), constipation, loss of appetite, stomach cancer, intestinal polyps, and liver and gallbladder disorders. Other uses include detoxification, treating menstrual cramps, cough, pain, breast lumps, chest pain (angina), fluid retention (edema), “hardening of the arteries” (arteriosclerosis), high blood pressure, asthma, gout, and osteoarthritis.
Some people apply greater celandine directly to the skin for warts, genital warts, rashes, eczema, and scabies; and to the gums for tooth pain and to ease tooth extraction. The fresh root is also chewed to relieve toothache.
How does it work?
The chemicals in greater celandine might slow the growth of cancer cells, but might also be harmful to normal cells. Preliminary research suggests greater celandine might increase the flow of bile. Greater celandine might also have some pain-relieving properties.
Possibly Effective for:
- Upset stomach (dyspepsia), when a combination of greater celandine and several other herbs is used. The combination (Iberogast, Medical Futures, Inc) includes greater celandine plus peppermint leaf, German chamomile, caraway, licorice, clown's mustard plant, lemon balm, angelica, and milk thistle. Research suggests that taking 1 mL of this combination three times daily over a period of 4 weeks significantly reduces severity of acid reflux, stomach pain, cramping, nausea and vomiting.
- Cancer. Developing research suggests a specific product, Ukrain, made from greater celandine might be useful for treating various forms of cancer. Some research shows that giving Ukrain intravenously under medical supervision might improve survival of some patients with colorectal, bladder, pancreatic, or breast cancer. But the studies that have shown this benefit have been criticized because they weren’t well designed. Some researchers suggest that doses of Ukrain that are high enough to shrink tumors might be too poisonous for medical use. Ukrain is not available in North America.
- Blister rashes.
- Pain and swelling (inflammation).
- Loss of appetite.
- Stomach flu.
- High blood pressure.
- Spasms in the digestive tract.
- Irregular menstrual periods.
- Other conditions.
GREATER CELANDINE Side Effects & Safety
Greater celandine might not be safe when taken by mouth. It can cause serious liver problems. When applied to the skin, greater celandine can cause allergic skin rash.
Not enough is known about the safety of giving greater celandine products intravenously.
Special Precautions & Warnings:Pregnancy and breast-feeding: Not enough is known about the use of greater celandine during pregnancy and breast-feeding. Stay on the safe side and avoid use.
Blockage of the bile duct (bile duct obstruction): Some greater celandine extracts appear to increase the flow of bile. There is a concern that this might make bile duct obstruction worse.
Liver disease, including hepatitis: There is some evidence that greater celandine can cause hepatitis. Don’t use greater celandine if you have liver disease.
Moderate Interaction Be cautious with this combination
- Medications that can harm the liver (Hepatotoxic drugs) interacts with GREATER CELANDINE
Greater celandine might harm the liver. Taking greater celandine along with medication that might also harm the liver can increase the risk of liver damage. Do not take greater celandine if you are taking a medication that can harm the liver.
Some medications that can harm the liver include acetaminophen (Tylenol and others), amiodarone (Cordarone), carbamazepine (Tegretol), isoniazid (INH), methotrexate (Rheumatrex), methyldopa (Aldomet), fluconazole (Diflucan), itraconazole (Sporanox), erythromycin (Erythrocin, Ilosone, others), phenytoin (Dilantin) , lovastatin (Mevacor), pravastatin (Pravachol), simvastatin (Zocor), and many others.
Before taking greater celandine, talk with your healthcare professional if you take any medications.
GREATER CELANDINE Dosing
The following doses have been studied in scientific research:
- For upset stomach, 1 mL three times daily of a specific combination product containing greater celandine plus peppermint leaf, German chamomile, caraway, licorice, clown's mustard plant, lemon balm, angelica, and milk thistle. (Iberogast, Medical Futures, Inc) over a period of 4 weeks.