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    Other Names:

    Beta-sitostanol, Bêta-sitostanol, Dihydro-beta-sitosterol, Ester de Stanol Végétal, Fucostanol, Phytostanol, Plant Stanol, Plant Stanol Esters, Stanol Végétal, Stigmastanol, 24-alpha-ethylcholestanol.

    SITOSTANOL Overview
    SITOSTANOL Side Effects
    SITOSTANOL Interactions
    SITOSTANOL Overview Information

    Sitostanol is a plant product. It is made from vegetable oils or the oil from pine tree wood pulp, and is then combined with canola oil. Sitostanol is used for prevention of heart disease and high cholesterol.

    Sitostanol is an ingredient in Benecol margarine and some salad dressings. The U.S. Food and Drug Administration (FDA) allows manufacturers of products that contain sitostanol or related plant chemicals (stanol esters) to claim that the product lowers the risk of getting coronary heart disease (CHD). The FDA reasons that sitostanol and other plant stanol esters along with a diet low in saturated fat and cholesterol might reduce the risk of CHD by lowering bloodcholesterol levels. Although there is plenty of evidence that sitostanol does lower cholesterol levels, so far there is no proof that long-term use actually lowers the risk of developing CHD.

    Do not confuse sitostanol with beta-sitosterol, an unsaturated plant sterol in the cholesterol-lowering margarine Take Control. Both sitostanol and beta-sitosterol are used for lower cholesterol levels in people with high cholesterol and appear to be equally effective.

    How does it work?

    Sitostanol blocks both the cholesterol from food and the cholesterol made by the liver from entering the body.

    SITOSTANOL Uses & Effectiveness What is this?

    Likely Effective for:

    • Reducing cholesterol levels. Sitostanol is effective for reducing cholesterol levels in adults with high cholesterol. It doesn't have to be taken with meals to work. Cholesterol levels decrease within 2 to 3 weeks of starting sitostanol, and return to pretreament levels within 2 to 3 weeks of discontinuation. Sitostanol may not have the same effect in all people. About 12% of patients do not respond to sitostanol.

      People usually take sitostanol as part of a sitostanol-enriched food such as margarine. Sitostanol alone can reduce total and “bad” low-density lipoprotein (LDL) cholesterol levels by 10% to 15%. Research suggests a dose of about 2 grams per day lowers cholesterol the most. Higher doses do not seem to work any better. When added to a cholesterol-lowering prescription medication (one of the “statins,” such as pravastatin (Pravachol) or simvastatin (Zocor), sitostanol reduces total cholesterol by an additional 3% to 11% and LDL cholesterol by another 7% to 16%.

      Sitostanol also seems to be effective for reducing cholesterol levels in healthy children. However, treating children is not recommended unless “bad” low-density lipoprotein (LDL) cholesterol levels are greater than 190 mg/dL or greater than 160 mg/dL if the child also has other risk factors for heart disease.

    Possibly Effective for:

    • Reducing cholesterol levels in children with an inherited tendency toward high cholesterol (familial hypercholesterolemia).

    SITOSTANOL Side Effects & Safety

    Sitostanol is safe for most people. It might cause stomach upset or too much fat in the stool (steatorrhea).

    Adults can safely use sitostanol for up to one year, and children can safely use it for up to three months.

    There is some concern that sitostanol might decrease absorption of some nutrients since it decreases fat absorption. Sitostanol does seem to reduce the absorption of dietary beta-carotene, but this reduction may not be important to health.

    Special Precautions & Warnings:

    Pregnancy and breast-feeding: Not enough is known about the use of sitostanol during pregnancy and breast-feeding. Stay on the safe side and avoid use.

    SITOSTANOL Interactions What is this?

    We currently have no information for SITOSTANOL Interactions


    The following doses have been studied in scientific research:


    • For high cholesterol: 800 mg to 4 grams of sitostanol per day have been tried. However, doses above 2 grams per day don't seem to work any better than 2 grams per day. Single daily doses seem to be as effective as divided doses administered twice or three times daily.

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    This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. © Therapeutic Research Faculty 2009.

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