PHOSPHATIDYLSERINE Overview Information
Phosphatidylserine is a chemical. The body can make phosphatidylserine, but gets most of what it needs from foods. Phosphatidylserine supplements were once made from cow brains, but now are commonly manufactured from cabbage or soy. The switch was triggered by a concern that products made from animal sources might cause infections such as mad cow disease.
Phosphatidylserine is used for Alzheimer's disease, age-related decline in mental function, improving thinking skills in young people, attention deficit-hyperactivity disorder (ADHD), depression, preventing exercise-induced stress, and improving athletic performance.
How does it work?
Phosphatidylserine is an important chemical with widespread functions in the body. It is part of the cell structure and is key in the maintenance of cellular function, especially in the brain.
Possibly Effective for:
- Alzheimer's disease. Taking phosphatidylserine can improve some of the symptoms of Alzheimer’s disease after 6-12 weeks of treatment. It seems to be most effective in patients with less severe symptoms. But phosphatidylserine might lose its effectiveness with extended use. After 16 weeks of treatment, progression of Alzheimer's disease seems to overcome any benefit provided by phosphatidylserine.
Most clinical studies have used phosphatidylserine from cow brains. However, most supplements now use phosphatidylserine from soy or cabbage. Researchers don’t know yet how phosphatidylserine made from these plant sources compares with phosphatidylserine made from cow brains in terms of effectiveness for Alzheimer’s disease.
- Confusion in older people (senile dementia). Phosphatidylserine made from cow brains seems to improve attention, language skills, and memory in aging people with declining thinking skills. It’s not known whether the newer products, which are taken from soy and cabbage, will have the same benefit. However, there is developing evidence that plant-derived phosphatidylserine improves memory in people with age-associated memory loss.
- Depression. There is some preliminary evidence that phosphatidylserine might improve depression in older people.
- Stress brought on by exercise. There is some evidence that athletes taking phosphatidylserine during strenuous training might feel better overall and have less muscle soreness.
- Improving athletic performance.
- Improving thinking ability.
- Attention deficit-hyperactivity disorder (ADHD).
- Other conditions.
PHOSPHATIDYLSERINE Side Effects & Safety
Phosphatidylserine is POSSIBLY SAFE for most people. It’s been used in research studies for up to six months.
Phosphatidylserine use can, however, cause side effects including insomnia and stomach upset, particularly at doses over 300 mg.
There is some concern that products made from animal sources could transmit diseases, such as mad cow disease. To date, there aren't any known cases of humans getting animal diseases from phosphatidylserine supplements, but look for supplements made from plants to be on the safe side.
Special Precautions & Warnings:Pregnancy and breast-feeding: Not enough is known about the use of phosphatidylserine during pregnancy and breast-feeding. Be on the safe side and avoid use.
Moderate Interaction Be cautious with this combination
- Drying medications (Anticholinergic drugs) interacts with PHOSPHATIDYLSERINE
Some drying medications are called anticholinergic drugs. Phosphatidylserine might increase chemicals that can decrease the effects of these drying medications.
Some drying medications include atropine, scopolamine, and some medications used for allergies (antihistamines) and for depression (antidepressants).
- Medications for Alzheimer's disease (Acetylcholinesterase (AChE) inhibitors) interacts with PHOSPHATIDYLSERINE
Phosphatidylserine might increase a chemical in the body called acetylcholine. Medications for Alzheimer's disease called acetylcholinesterase inhibitors also increase the chemical acetylcholine. Taking phosphatidylserine along with medications for Alzheimer's disease might increase effects and side effects of medications for Alzheimer's disease.
Some acetylcholinesterase medications include donepezil (Aricept), tacrine (Cognex), rivastigmine (Exelon), and galantamine (Reminyl, Razadyne).
- Various medications used for glaucoma, Alzheimer's disease, and other conditions (Cholinergic drugs) interacts with PHOSPHATIDYLSERINE
Phosphatidylserine might increase a chemical in the body called acetylcholine. This chemical is similar to some medications used for glaucoma, Alzheimer's disease, and other conditions. Taking phosphatidylserine with these medications might increase the chance of side effects.
Some of these medications used for glaucoma, Alzheimer's disease, and other conditions include pilocarpine (Pilocar and others), and others.
The following doses have been studied in scientific research:
- For Alzheimer's disease, and other age-related thinking or memory impairment: 100 mg of phosphatidylserine three times daily.