Reviewer: pearl, 45-54 Female on Treatment for 10 years or more (Consumer)

Comment:
I have an overall improved sense of well being and calm with SAMe. Started taking this in 2001 and find that I don't feel as well without it. My concentration is better and I am able to focus on tasks. I have read multiple comments about upset stomach. I started at 200mg per day and now only take 400mg but have no side effects. My daughter takes this when her mood is low from PMS and she also find ... Show Full Comment

Comment:
I have an overall improved sense of well being and calm with SAMe. Started taking this in 2001 and find that I don't feel as well without it. My concentration is better and I am able to focus on tasks. I have read multiple comments about upset stomach. I started at 200mg per day and now only take 400mg but have no side effects. My daughter takes this when her mood is low from PMS and she also finds it helpful.
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Reviewer: mudopud, 45-54 Female on Treatment for less than 1 month (Consumer)

Comment:
Only started taking 400mg of NatureMade Sam-e Complete 9 days ago. Only thing noticed so far is very sick stomach. I take it upon rising on empty stomach and wait at least 30mins to 1 hour to eat per directions. I have a strong burning sensation in stomach and esophagus even though I take prevacid every night b4 bed. Eating antacids like crazy to help with discomfort. Starting to have very loose v ... Show Full Comment

Comment:
Only started taking 400mg of NatureMade Sam-e Complete 9 days ago. Only thing noticed so far is very sick stomach. I take it upon rising on empty stomach and wait at least 30mins to 1 hour to eat per directions. I have a strong burning sensation in stomach and esophagus even though I take prevacid every night b4 bed. Eating antacids like crazy to help with discomfort. Starting to have very loose very light colored stool now too. Not sure that I can continue with the discomfort I am experiencing. I also wake up after only 2 to 3 hours of sleep and have trouble falling back to sleep. I may try to cut back to 200mg for a few days and see what happens. Dr gave me welbutrin, but I am trying to avoid taking it.
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Reviewer: Better Off, 45-54 Male on Treatment for 2 to less than 5 years (Consumer)

Comment:
I have taken Sam-E for multiple conditions. It started with depression. It has been effective for me. I understand that Sam-E is produced naturally by your body. If you get an effect from Sam-E, it is because your body does not produce enough of it, so the supplement helps the deficit. If you take too much, then the side effects kick in. Over time I have reduced my Sam-E dosage to 200 per d ... Show Full Comment

Comment:
I have taken Sam-E for multiple conditions. It started with depression. It has been effective for me. I understand that Sam-E is produced naturally by your body. If you get an effect from Sam-E, it is because your body does not produce enough of it, so the supplement helps the deficit. If you take too much, then the side effects kick in. Over time I have reduced my Sam-E dosage to 200 per day. This seems to work for me. I also have knee joint problems. I have had less pain pain since taking it.
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Reviewer: George, 45-54 Male on Treatment for less than 1 month (Caregiver)

Comment:
Both my wife and daughter tried SAMe starting at 400 mg bid for depression. My wife developed boring, epigastric pain immediately, stopped for a week, restarted and the pain recurred. She stopped taking it before any mood effects could be seen. Her daughter (concurrently taking Wellbutrin)took the same dose out of the same package for 5 days, with worsening epigastric pain each day. On the 5th ... Show Full Comment

Comment:
Both my wife and daughter tried SAMe starting at 400 mg bid for depression. My wife developed boring, epigastric pain immediately, stopped for a week, restarted and the pain recurred. She stopped taking it before any mood effects could be seen. Her daughter (concurrently taking Wellbutrin)took the same dose out of the same package for 5 days, with worsening epigastric pain each day. On the 5th day she was taken to the ER via ambulance, unable to stand, with severe epigastric pain. Ultrasound and bloodwork were normal. She was discharged with a prescription for a proton pump inhibitor, diagnosis: presumed gastritis. I can't rule out a genetic component here, but also can't rule out a problem with this particular brand/lot. There may also have been an interaction with Wellbutrin. Bottom line: I suspect GI side effects with SAMe can be more severe, and more common than the marketing materials would suggest!
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Reviewer: colungag, 35-44 Male on Treatment for 1 to 6 months (Consumer)

Comment:
SAM-e worked great for my mood. I had a general sense well being all the time. I was able to cut back to half dose of my effexor. The new combination made me feel better than the full dose. HOWEVER, I experience some mild constipation along with rectal inflammation. Also, I was unable to taste anything while I was on it. Each time I stopped, the inflammation resolved as well as the taste issue an ... Show Full Comment

Comment:
SAM-e worked great for my mood. I had a general sense well being all the time. I was able to cut back to half dose of my effexor. The new combination made me feel better than the full dose. HOWEVER, I experience some mild constipation along with rectal inflammation. Also, I was unable to taste anything while I was on it. Each time I stopped, the inflammation resolved as well as the taste issue and would resume whenever I restarted the sam-e. I regret not being able to continue it.
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