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Polio Virus Created From Scratch in Lab

Will Smallpox Be Next? Not Likely, Scientists Say
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WebMD Health News

July 12, 2002 -- Just to show it could be done, scientists have reconstructed the polio virus in their laboratory -- using information they pulled off the Internet and materials available by mail order. It's the first time this has been done. Others are asking: What impact does this have on bioterrorism?

"I think it would be wrong to close our eyes to this," study author Eckard Wimmer, PhD, professor of microbiology at The University of New York at Stony Brook, tells WebMD.

His paper appears in the July 11 issue of Science.

"We have taken information that's in the public domain to re-create the virus in a test tube. It's something any good laboratory could do," says Wimmer.

The virus' chemical sequence, genetic map, and three-dimensional structure were actually outlined two decades ago. However, this is the first time that a genome has been reconstructed without a natural virus to build from, he says.

In his experiments, Wimmer injected the virus into mice to show it worked to paralyze the animals. The mice were then killed.

"Poliovirus normally grows in the gut," he explains. "Only rarely does it find its way into the central nervous system. Once it's there, it looks for [nerves located] in the muscles, and the result is paralysis."

Polio has been virtually eradicated worldwide due an extensive vaccination campaign by the World Health Organization.

"When we say it's been eradicated, that means eradicated from circulation in global populations," says Wimmer. "But there's still an enormous amount of virus available in laboratory freezers around the world -- tens of thousands of laboratories. Efforts are only under way now to contain these laboratory specimens."

Those polio samples are kept for research, he says. Other laboratories may have specimens simply by accident. "Specimens of common diarrhea may actually contain poliovirus. It's very difficult to eradicate from laboratories."

But does this unveil a new smallpox threat? No, says Wimmer. "Polio is a very simple virus," he tells WebMD. "The smallpox virus is much, much larger, and to put it together from scratch right now is almost impossible. Smallpox could not be re-created now, but maybe in 20-30 years when technology is more advanced. You could re-create hepatitis B or C, but these are not terrorist agents."

In fact, any poliovirus released into the population right now "wouldn't do any harm whatsoever because we're all so protected," Wimmer tells WebMD. "Some say that poliovirus isn't necessarily a bioterrorist agent because it doesn't kill. We can debate whether killing is necessary to really cause terror. I don't think it is."

Patrolling the Internet for information, or screening buyers, is not necessary, he adds. "A bioterrorist would be sophisticated enough to use samples from laboratories.

"It would be a big mistake to curtail dissemination of information, because information even about dangerous pathogens leads to useful research to combat impact of these pathogens, including development of drugs against it or means to protect our immune systems. Curtailing free flow of information I believe is counterproductive," says Wimmer.

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