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Lengthy HRT Use May Up Ovarian Cancer

Risk Seen in Women Taking Hormone Replacement Therapy for 5 or More Years

HRT Study's Results

Over five years, there was one extra ovarian cancer in roughly 2,500 HRT users and one extra ovarian cancer death in about 3,300 HRT users, Beral's team notes.

The increased risk of ovarian cancer only occurred in women who currently used HRT and had done so for at least five years.

Women who had quit HRT use -- and those who had used HRT for less than five years -- weren't at increased risk of ovarian cancer, compared to women who had never used HRT.

The type of HRT didn't affect the results.

The study, published in The Lancet, doesn't prove that HRT causes ovarian cancers.

But the results held when the researchers adjusted for factors including age, time since menopause, smoking, physical activity, age at first birth, BMI (body mass index), alcohol consumption, past use of oral contraceptives, social class, and geographic location.

HRT Editorial

The ovarian cancer risk seen in the study "might be thought of as small, but enormous numbers of women have been exposed" through HRT use, states an editorial in The Lancet.

HRT use has dropped based on previous studies showing other health risks with long-term HRT use, notes editorialist Steven Narod, MD, FRCP.

Narod directs the Familial Breast Cancer Research Unit at the Women's College Research Institute and is also a professor in the public health sciences department at the University of Toronto.

"With these new data on ovarian cancer, we expect the use of HRT to fall further," writes Narod. We hope that the number of women dying of ovarian cancer will decline as well."

Short-Term HRT Use

The American Society for Reproductive Medicine (ASRM) issued a statement about the study.

"Although long-term use of estrogen appears to increase the risk of ovarian cancer, women should be reassured that short-term use for symptomatic treatment at or near menopause is unlikely to increase the risk of ovarian cancer appreciably," says Robert Rebar, MD, ASRM executive director, in the statement.

"These data, added together with the most recent data from the Women's Health Initiative, provide reassurance all-in-all that short-term use of estrogen is not harmful to symptomatic women," says Rebar.

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