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    Paget's Disease of the Breast

    Important
    It is possible that the main title of the report Paget's Disease of the Breast is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

    Synonyms

    Disorder Subdivisions

    • None

    General Discussion

    Summary
    Paget's disease of the breast is a rare form of breast cancer that almost exclusively occurs in women. However, rare cases have been reported in men. Paget's disease of the breast is characterized by inflammatory, "eczema-like" changes of the nipple that may extend to involve the areola, which is the circular, darkened (pigmented) region of skin surrounding the nipple. Initial findings often include itching (pruritus), scaling, and crusting of and/or discharge from the nipple. In individuals with Paget's disease of the breast, distinctive tumor cells (known as Paget cells) are present within the outermost layer of skin (epidermis) of the nipple, when viewed under a microscope. Most women with this disorder have an underlying cancer (malignancy) affecting the milk ducts (ductal carcinoma). The milk ducts are the channels that carry milk secreted by lobes of the breast to the nipple. The exact cause of Paget's disease of the breast is not fully understood.

    Introduction
    Paget's disease of the breast was originally reported in 1874 by Sir James Paget, an English surgeon, who also described an unrelated skeletal condition known as Paget's disease of the bone. It is essential to note that these disorders are distinct entities that are medically unrelated.

    Resources

    National Women's Health Network
    1413 K Street, NW
    4th Floor
    Washington, DC 20005
    USA
    Tel: (202)682-2640
    Fax: (202)682-2648
    Email: nwhn@nwhn.org
    Internet: http://www.womenshealthnetwork.org

    Skin Cancer Foundation
    149 Madison Avenue
    Suite 901
    New York, NY 10016
    Tel: (212)725-5176
    Fax: (212)725-5751
    Tel: (800)754-6490
    Email: info@skincancer.org
    Internet: http://www.skincancer.org

    American Cancer Society, Inc.
    250 Williams NW St
    Ste 6000
    Atlanta, GA 30303
    USA
    Tel: (404)320-3333
    Tel: (800)227-2345
    TDD: (866)228-4327
    Internet: http://www.cancer.org

    Rose Kushner 's Women's Breast Cancer Advisory Center
    P.O. Box 757
    Malaga Cove, CA 90274
    Email: lkkushner@yahoo.com
    Internet: http://www.rkbcac.org/

    National Cancer Institute Physician Data Query
    Office of Communications and Education
    Public Inquiries Office
    6116 Executive Blvd
    Suite 300
    Bethesda, MD 20892-8322
    Tel: (800)422-6237
    Email: cancergovstaff@mail.nih.gov
    Internet: http://www.cancer.gov/cancertopics/pdq/cancerdatabase

    National Cancer Institute
    6116 Executive Blvd Suite 300
    Bethesda, MD 20892-8322
    USA
    Tel: (301)435-3848
    Tel: (800)422-6237
    TDD: (800)332-8615
    Email: cancergovstaff@mail.nih.gov
    Internet: http://www.cancer.gov

    OncoLink: The University of Pennsylvania Cancer Center Resource
    3400 Spruce Street
    2 Donner
    Philadelphia, PA 19104-4283
    USA
    Tel: (215)349-8895
    Fax: (215)349-5445
    Email: hampshire@uphs.upenn.edu
    Internet: http://www.oncolink.upenn.edu

    SHARE - Self-Help For Women With Breast or Ovarian Cancer
    1501 Broadway
    Suite 704A
    New York, NY 10036
    Tel: (212)719-0364
    Fax: (212)869-3431
    Tel: (866)891-2392
    Email: info@sharecancersupport.org
    Internet: http://www.sharecancersupport.org/

    Canadian Breast Cancer Network
    331 Cooper Street, Suite 300
    Ottawa
    Ontario, K2P 0G5
    Canada
    Tel: 6132303044
    Fax: 6132304424
    Tel: 8006858820
    Email: cbcn@cbcn.ca
    Internet: http://www.cbcn.ca

    Breast Cancer Society of Canada
    420 East Street North
    Sarnia
    Ontario, N7T 6Y5
    Canada
    Tel: 5193360746
    Fax: 5193365725
    Tel: 8005678767
    Email: bcsc@bcsc.ca
    Internet: http://www.bcsc.ca

    Rare Cancer Alliance
    1649 North Pacana Way
    Green Valley, AZ 85614
    USA
    Internet: http://www.rare-cancer.org

    Genetic and Rare Diseases (GARD) Information Center
    PO Box 8126
    Gaithersburg, MD 20898-8126
    Tel: (301)251-4925
    Fax: (301)251-4911
    Tel: (888)205-2311
    TDD: (888)205-3223
    Internet: http://rarediseases.info.nih.gov/GARD/

    Friends of Cancer Research
    1800 M Street NW
    Suite 1050 South
    Washington, DC 22202
    Tel: (202)944-6700
    Email: info@focr.org
    Internet: http://www.focr.org

    Cancer Support Community
    1050 17th St NW Suite 500
    Washington, DC 20036
    Tel: (202)659-9709
    Fax: (202)974-7999
    Tel: (888)793-9355
    Internet: http://www.cancersupportcommunity.org/

    Lance Armstrong Foundation
    2201 E. Sixth Street
    Austin, TX 78702
    Tel: (512)236-8820
    Fax: (512)236-8482
    Tel: (877)236-8820
    Email: media@livestrong.org
    Internet: http://www.livestrong.org

    For a Complete Report:

    This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".

    The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

    It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

    This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

    For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

    Last Updated: 3/27/2012
    Copyright 1990, 2000, 2012 National Organization for Rare Disorders, Inc.

    WebMD Medical Reference from the National Organization for Rare Disorders

    Last Updated: May 28, 2015
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.

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