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Can antidepressants cause weight gain?

Psychiatrist, WebMD Medical Expert
American Medical Association

Most of the antidepressants, and probably all of the mood stabilizers, can and do cause weight gain. Bupropion -- commonly known as Aplenzin, Wellbutrin, or Zyban -- usually does suppress appetite and can result in less weight gain than other antidepressants.

Within each class of medications, there are some that are more weight-gain prone and others that are a bit more friendly. Ask your doctor specifically about the more weight-friendly ones. Also be careful in that weight gain may lead to diabetes and cholesterol problems. If you have gained, ask your doctor to check on these and blood pressure, too.