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Effects of Diethylstilbestrol (DES) Exposure - Topic Overview

Between 1948 and 1971, millions of women took a drug called diethylstilbestrol (DES) to prevent miscarriage.

Daughters born to women who took DES while pregnant have a slightly higher risk of developing:

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Study Design Categories, Definitions, and Levels of Evidence

Prospective, randomized, controlled trials and meta-analyses of prospective, randomized, controlled trials. The randomized, double-blinded, controlled trial is the gold standard of study design. To achieve this ranking, the study allocation must be blinded to the investigator both before and after the randomization and the assignment to intervention group. This design provides protection from allocation bias by the investigator and from bias in the assessment of outcomes by both the...

Read the Study Design Categories, Definitions, and Levels of Evidence article > >

    This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http:// cancer .gov or call 1-800-4-CANCER.

    WebMD Medical Reference from Healthwise

    Last Updated: March 12, 2014
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
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