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How effective is vitamin B-12 (cobalamin) at treating elevated levels of homocysteine in the blood?

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There is some conflicting evidence about using vitamin B-12 to treat elevated levels of homocysteine in the blood. It is not fully understood how or if this elevation contributes to heart disease and other problems with blood vessels, or if the elevation is a result of these conditions. A high level of homocysteine in the blood is a risk factor for coronary, cerebral, and peripheral blood vessel disease. Risks also include blood clots, heart attacks, and certain types of stroke. Since the evidence for treating elevated levels of homocysteine in the blood remains conflicting, the current recommendation is screening of men over age 40 and women over age 50. For patients with elevated homocysteine levels, the recommendation is to supplement with folic acid and vitamin B-12. You should talk to your doctor before treating yourself for these conditions.

SOURCES:

Longe, J., ed. , second edition, 2004. The Gale Encyclopedia of Alternative Medicine

Natural Standard Patient Monograph: "Vitamin B-12."

Office of Dietary Supplements web site: "Vitamin B-12."

Toole J.F. 2004. Journal of the American Medical Association,

Hanley, D.F. 2004. Journal of the American Medical Association,

Landgren, F. , 1995. Journal of Internal Medicine

Christensen, B. , 1999. Atherosclerosis

Nallamothu, B.K. , 2000. Archives of Internal Medicine

Christen, W.G. , 2009. Archives of Internal Medicine

Reviewed by Nayana Ambardekar on January 20, 2019

SOURCES:

Longe, J., ed. , second edition, 2004. The Gale Encyclopedia of Alternative Medicine

Natural Standard Patient Monograph: "Vitamin B-12."

Office of Dietary Supplements web site: "Vitamin B-12."

Toole J.F. 2004. Journal of the American Medical Association,

Hanley, D.F. 2004. Journal of the American Medical Association,

Landgren, F. , 1995. Journal of Internal Medicine

Christensen, B. , 1999. Atherosclerosis

Nallamothu, B.K. , 2000. Archives of Internal Medicine

Christen, W.G. , 2009. Archives of Internal Medicine

Reviewed by Nayana Ambardekar on January 20, 2019

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How effective is vitamin B-12 (cobalamin) at reducing the risk for age-related macular degeneration?

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