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What are symptoms of acute porphyria?

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The symptoms of acute porphyria can form quickly and last for days or weeks. A salt imbalance sometimes accompanies an episode of this type of porphyria. The imbalance can contribute to some of these symptoms:

  • Abdominal pain, often severe
  • Chest pain
  • Increased heart rate and blood pressure
  • Limb and back pain
  • Muscle weakness
  • Tingling
  • Loss of sensation
  • Cramping
  • Vomiting and constipation
  • Personality changes or mental disorders
  • Agitation, confusion, and seizures

Long-term complications in some patients have included:

  • Chronic pain
  • Depression
  • Kidney damage
  • Liver cancer

SOURCES:

National Human Genome Research Institute: "Learning about Porphyria."

NIH Rare Diseases Clinical Research Network: "Porphyria Overview," "Treatment and Prevention," "Acute Intermittent Porphyria," "Frequently Asked Questions"

American Porphyria Foundation: "Porphyria Cutanea Tarda," "Congenital Erythropoietic Porphyria (CEP)," "Variegate Porphyria (VP)," "Hepatoerythropoietic Porphyria (HEP)," "ALAD-Deficiency Porphyria (ADP)," "About Porphyria."

Genetic and Rare Diseases Information Center: "Porphyria Cutanea Tarda."

Reviewed by Arefa Cassoobhoy on July 15, 2020

SOURCES:

National Human Genome Research Institute: "Learning about Porphyria."

NIH Rare Diseases Clinical Research Network: "Porphyria Overview," "Treatment and Prevention," "Acute Intermittent Porphyria," "Frequently Asked Questions"

American Porphyria Foundation: "Porphyria Cutanea Tarda," "Congenital Erythropoietic Porphyria (CEP)," "Variegate Porphyria (VP)," "Hepatoerythropoietic Porphyria (HEP)," "ALAD-Deficiency Porphyria (ADP)," "About Porphyria."

Genetic and Rare Diseases Information Center: "Porphyria Cutanea Tarda."

Reviewed by Arefa Cassoobhoy on July 15, 2020

From: Porphyria

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