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What causes autosomal dominant polycystic kidney disease (ADPKD)?

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ADPKD is caused by a problem with one of two genes in your DNA -- PKD1 or PKD2. These genes make proteins in kidney cells that let them know when to grow. A problem with either gene causes kidney cells to grow out of control and form cysts.

Many genetic diseases happen when a person gets broken genes from both parents, but with ADPKD you need only one faulty gene to have the disease. That's why this kind of PKD is called “autosomal dominant,” meaning only one parent has to pass on a broken gene.

SOURCES:

National Human Genome Research Institute: "Learning About Autosomal Dominant Polycystic Kidney Disease."

National Kidney Foundation: "Polycystic Kidney Disease."

PKD International: "ADPKD."

PKD Foundation: "Common Questions About How PKD Will Affect Your Health."

Halvorson, C. International Journal of Nephrology and Renovascular Disease, June 2010.

Reviewed by Minesh Khatri on August 19, 2020

SOURCES:

National Human Genome Research Institute: "Learning About Autosomal Dominant Polycystic Kidney Disease."

National Kidney Foundation: "Polycystic Kidney Disease."

PKD International: "ADPKD."

PKD Foundation: "Common Questions About How PKD Will Affect Your Health."

Halvorson, C. International Journal of Nephrology and Renovascular Disease, June 2010.

Reviewed by Minesh Khatri on August 19, 2020

NEXT QUESTION:

What are your chances of getting autosomal dominant polycystic kidney disease (ADPKD) if one parent has the disease?

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