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What is rituximab (rituxan) and how can it help in treating thrombocytopenia and immune thrombocytopenia (ITP)?

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Rituximab (Rituxan) is a type of drug called biologics. It attacks B cells, a type of white blood cell that can destroy platelets. ITP causes thrombocytopenia, a blood clotting disorder. Rituximab is sometimes used if you have severe ITP despite treatment with steroids and you aren't able to have surgery to remove your spleen. Your doctor may also suggest it if you've had your spleen removed but you still have low platelet counts.

From: Thrombocytopenia and ITP WebMD Medical Reference

SOURCES:

 

Hoffman, R.  , 5th edition, Churchill Livingstone Elsevier, 2009. Hematology: Basic Principles and Practice

 

National Institutes of Health: "How Is Thromobocytopenia Diagnosed?" "Living With Thrombocytopenia."

 

Cleveland Clinic: "Thrombocytopenia."

 

Platelet Disorder Support Association: "Food as a Cure."

 

American Academy of Family Physicians: "Idiopathic Thrombocytopenic Purpura (ITP)."

 

ITP Foundation: "What Is ITP?"

 

UptoDate: "Immune thrombocytopenia (ITP) in adults."

 

FDA: "FDA approves fostamatinib tablets for ITP," April 2018.

 

Medscape: "Rituximab: An anti-CD20 Antibody for the Treatment of Chronic Refractory Immune Thrombocytopenic Purpura."

Reviewed by Arefa Cassoobhoy on November 12, 2018

SOURCES:

 

Hoffman, R.  , 5th edition, Churchill Livingstone Elsevier, 2009. Hematology: Basic Principles and Practice

 

National Institutes of Health: "How Is Thromobocytopenia Diagnosed?" "Living With Thrombocytopenia."

 

Cleveland Clinic: "Thrombocytopenia."

 

Platelet Disorder Support Association: "Food as a Cure."

 

American Academy of Family Physicians: "Idiopathic Thrombocytopenic Purpura (ITP)."

 

ITP Foundation: "What Is ITP?"

 

UptoDate: "Immune thrombocytopenia (ITP) in adults."

 

FDA: "FDA approves fostamatinib tablets for ITP," April 2018.

 

Medscape: "Rituximab: An anti-CD20 Antibody for the Treatment of Chronic Refractory Immune Thrombocytopenic Purpura."

Reviewed by Arefa Cassoobhoy on November 12, 2018

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What are the side effects of rituximab while treating thrombocytopenia and immune thrombocytopenia (ITP)?

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