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What medical conditions can cause thrombocytopenia?

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Thrombocytopenia is a condition when you don’t have enough blood-clotting platelets in your blood. Medical conditions that can cause it include:

  • Blood cancer such as leukemia or lymphoma
  • A problem with your bone marrow, like toxicity from alcohol use
  • Vitamin B12 or folate (vitamin B9) deficiency
  • Pregnancy. Up to 5% of healthy women get it during pregnancy, and it usually gets better on its own after your baby is born. But it can also be a sign of something more concerning, like preeclampsia or HELLP syndrome.
  • An enlarged spleen
  • Your body uses too many platelets, leaving you without enough of them. That can happen if you have an autoimmune disease, like rheumatoid arthritis or lupus.
  • Rare disorders like hemolytic uremic syndrome and thrombotic thrombocytopenic purpura (TTP), [LB5] [AC6] which uses a lot of platelets to make small blood clots throughout your body.

From: Thrombocytopenia and ITP WebMD Medical Reference

SOURCES:

 

Hoffman, R.  , 5th edition, Churchill Livingstone Elsevier, 2009. Hematology: Basic Principles and Practice

 

National Institutes of Health: "How Is Thromobocytopenia Diagnosed?" "Living With Thrombocytopenia."

 

Cleveland Clinic: "Thrombocytopenia."

 

Platelet Disorder Support Association: "Food as a Cure."

 

American Academy of Family Physicians: "Idiopathic Thrombocytopenic Purpura (ITP)."

 

ITP Foundation: "What Is ITP?"

 

UptoDate: "Immune thrombocytopenia (ITP) in adults."

 

FDA: "FDA approves fostamatinib tablets for ITP," April 2018.

 

Medscape: "Rituximab: An anti-CD20 Antibody for the Treatment of Chronic Refractory Immune Thrombocytopenic Purpura."

Reviewed by Arefa Cassoobhoy on November 12, 2018

SOURCES:

 

Hoffman, R.  , 5th edition, Churchill Livingstone Elsevier, 2009. Hematology: Basic Principles and Practice

 

National Institutes of Health: "How Is Thromobocytopenia Diagnosed?" "Living With Thrombocytopenia."

 

Cleveland Clinic: "Thrombocytopenia."

 

Platelet Disorder Support Association: "Food as a Cure."

 

American Academy of Family Physicians: "Idiopathic Thrombocytopenic Purpura (ITP)."

 

ITP Foundation: "What Is ITP?"

 

UptoDate: "Immune thrombocytopenia (ITP) in adults."

 

FDA: "FDA approves fostamatinib tablets for ITP," April 2018.

 

Medscape: "Rituximab: An anti-CD20 Antibody for the Treatment of Chronic Refractory Immune Thrombocytopenic Purpura."

Reviewed by Arefa Cassoobhoy on November 12, 2018

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