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What should you know about using clonidine (Kapvay) and guanfacine (Intuniv) to treat ADHD?

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Clonidine and guanfacine can help reduce some of the side effects of stimulant therapy, especially sleeplessness and aggressive behavior. However, combining stimulants with one of these drugs is controversial, because there have been some deaths in children taking both stimulants and Catapres (a patch form of clonidine).

It is unclear whether these deaths were due to the combination of drugs, but caution should be exercised whenever such combinations are used. Careful screening for heart rhythm irregularities and regular monitoring of blood pressure and electrocardiograms help reduce these risks. If your doctor thinks that combining these two treatments offers more benefits than risks, it may be a good option.

SOURCES:

Strattera web site.

Kapvay web site: "Monthly Prescribing Reference."

Food and Drug Administration.

American Academy of Childhood and Adolescent Psychiatry.

Medscape web site: “Once-Daily Guanfacine Approved to Treat ADHD.”

Intuniv web site.

Attention Deficit Disorder Resources web site: “Medication Management for Adults with ADHD.”

WebMD Medical Reference: “Should My Child Take Stimulant Medications for ADHD?"

National Institute of Mental Health web site: “Questions Raised about Stimulants and Sudden Death.”

HelpGuide.org web site: “ADD & ADHD Medications.”

Reviewed by Smitha Bhandari on June 11, 2017

SOURCES:

Strattera web site.

Kapvay web site: "Monthly Prescribing Reference."

Food and Drug Administration.

American Academy of Childhood and Adolescent Psychiatry.

Medscape web site: “Once-Daily Guanfacine Approved to Treat ADHD.”

Intuniv web site.

Attention Deficit Disorder Resources web site: “Medication Management for Adults with ADHD.”

WebMD Medical Reference: “Should My Child Take Stimulant Medications for ADHD?"

National Institute of Mental Health web site: “Questions Raised about Stimulants and Sudden Death.”

HelpGuide.org web site: “ADD & ADHD Medications.”

Reviewed by Smitha Bhandari on June 11, 2017

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