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What are N-methyl-D-aspartate (NMDA) receptor antagonists?

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NMDA (short for N-methyl-D-aspartate) receptor antagonists are a class of drugs that may help treat Alzheimer's disease, which causes memory loss, brain damage, and, eventually, death. There's no cure for Alzheimer's, but some drugs may slow it down.

SOURCES:

Alzheimer's Association: "Current treatments."

Strong, K. , October 2014. Expert Opinion on Therapeutic Patents

Chen, H. , June 2006. Journal of Neurochemistry

Deardorff, W. . Published online, July 2016. Expert Opinion on Pharmacotherapy

Esposito, Z. , April 2013. CNS Neuroscience and Therapeutics

Zarate, C. , October 2010. Harvard Review of Psychiatry

Olivares, D. , July 2012. Current Alzheimer Research

Kapur, S. , September 2002. Molecular Psychiatry

National Institute on Drug Abuse: "DrugFacts: Hallucinogens."

University of Maryland, Center for Substance Abuse Research: "Ketamine."

Cleveland Clinic: "Hallucinogens -- LSD, Peyote, Psilocybin and PCP."

News release, University of Cincinnati: "Ketamine Shows Promise as Therapy for Brain Trauma and Mood Disorders."

Reviewed by Lisa Bernstein on August 01, 2018

SOURCES:

Alzheimer's Association: "Current treatments."

Strong, K. , October 2014. Expert Opinion on Therapeutic Patents

Chen, H. , June 2006. Journal of Neurochemistry

Deardorff, W. . Published online, July 2016. Expert Opinion on Pharmacotherapy

Esposito, Z. , April 2013. CNS Neuroscience and Therapeutics

Zarate, C. , October 2010. Harvard Review of Psychiatry

Olivares, D. , July 2012. Current Alzheimer Research

Kapur, S. , September 2002. Molecular Psychiatry

National Institute on Drug Abuse: "DrugFacts: Hallucinogens."

University of Maryland, Center for Substance Abuse Research: "Ketamine."

Cleveland Clinic: "Hallucinogens -- LSD, Peyote, Psilocybin and PCP."

News release, University of Cincinnati: "Ketamine Shows Promise as Therapy for Brain Trauma and Mood Disorders."

Reviewed by Lisa Bernstein on August 01, 2018

NEXT QUESTION:

How can NMDA receptor antagonist drugs help with Alzheimer's disease?

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