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How do the leukotriene modifiers improve asthma control?

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Montelukast (Singulair), zafirlukast (Accolate), and zileuton (Zyflo) are called leukotriene modifiers. Leukotrienes are inflammatory chemicals that occur naturally in our bodies and cause tightening of airway muscles and production of mucus. Leukotriene modifier drugs help control asthma by blocking the actions of leukotrienes in the body. Studies show that these medications are helpful in improving airflow and reducing asthma symptoms.

The leukotriene modifiers are taken as pills and have been shown to decrease the need for other asthma medications. These medications have also been shown to be effective in people with allergic rhinitis (nasal allergies) and may be effective in people with both allergic rhinitis and allergic asthma.

SOURCES:

American Academy of Allergy, Asthma & Immunology: "Asthma Medications."

American Lung Association: "Long-Term Control Medications."

Asthma and Allergy Foundation of America: "Non-Allergic Asthma."

Boehringer Ingelheim: "US FDA Expands Approval of Tiotropium Respimat® for Maintenance Treatment of Asthma in Children."

FDA News Release. “FDA approves Cinqair to treat severe asthma.”

FDA. Prescribing Information: Spiriva Respimat.

News release, Merck.

News release, GlaxoSmithKline.

NIH, MedlinePlus: "Omalizumab Injection."

 

Reviewed by Carol DerSarkissian on August 11, 2019

SOURCES:

American Academy of Allergy, Asthma & Immunology: "Asthma Medications."

American Lung Association: "Long-Term Control Medications."

Asthma and Allergy Foundation of America: "Non-Allergic Asthma."

Boehringer Ingelheim: "US FDA Expands Approval of Tiotropium Respimat® for Maintenance Treatment of Asthma in Children."

FDA News Release. “FDA approves Cinqair to treat severe asthma.”

FDA. Prescribing Information: Spiriva Respimat.

News release, Merck.

News release, GlaxoSmithKline.

NIH, MedlinePlus: "Omalizumab Injection."

 

Reviewed by Carol DerSarkissian on August 11, 2019

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What are the side effects of leukotriene modifiers for asthma?

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