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What can the levels of the different substances measured during a quad marker screen mean?

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The expected amount of substances measured during a quad marker screen changes weekly during pregnancy, so tell your health care providers how long you’ve been pregnant.

High AFP levels may mean the fetus has an open neural tube defect, the fetus is older than was thought, or the woman is expecting twins. Low AFP levels may mean the baby has a higher risk of having Down syndrome.

High hCG and inhibin-A levels may mean the baby has a higher risk of Down syndrome, as can low estriol levels.

From: Pregnancy and the Quad Marker Screen WebMD Medical Reference

Reviewed by Trina Pagano on September 19, 2016

Medically Reviewed on 09/19/2016

SOURCES: The March of Dimes.  , "Second trimester maternal serum screening for fetal open neural tube defects and aneuploidy." American College of Medical Genetics, 2004.


Deborah A. Driscoll, MD

Reviewed by Trina Pagano on September 19, 2016

SOURCES: The March of Dimes.  , "Second trimester maternal serum screening for fetal open neural tube defects and aneuploidy." American College of Medical Genetics, 2004.


Deborah A. Driscoll, MD

Reviewed by Trina Pagano on September 19, 2016

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How safe is the quad marker screen?

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