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What happens during the quad marker screen, and how accurate is it?

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The quad marker screen uses a sample of blood from your vein to screen for:

  • Problems in the development of the fetus's brain and spinal cord, called open neural tube defects. The test can predict about 75%-80% of open neural tube defect cases.
  • Genetic disorders such as Down syndrome. The test can predict about 75% of Down syndrome cases in women under 35, and over 80% of cases in women ages 35 and older.

From: Pregnancy and the Quad Marker Screen WebMD Medical Reference

Reviewed by Trina Pagano on September 19, 2016

Medically Reviewed on 09/19/2016

SOURCES: The March of Dimes.  , "Second trimester maternal serum screening for fetal open neural tube defects and aneuploidy." American College of Medical Genetics, 2004.


Deborah A. Driscoll, MD

Reviewed by Trina Pagano on September 19, 2016

SOURCES: The March of Dimes.  , "Second trimester maternal serum screening for fetal open neural tube defects and aneuploidy." American College of Medical Genetics, 2004.


Deborah A. Driscoll, MD

Reviewed by Trina Pagano on September 19, 2016

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When should I get a quad marker screen?

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