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What are the symptoms of ankylosing spondylitis?

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The most common early symptoms of ankylosing spondylitis include:

Ankylosing spondylitis is a systemic disease, which means symptoms may not be limited to the joints. People with the condition also may have fever, fatigue, and loss of appetite. Eye inflammation (redness and pain) occurs in some people with spondylitis. In rare cases, lung and heart problems also may develop.

  • Pain and stiffness -- Constant pain and stiffness in the low back, buttocks, and hips that continue for more than three months. Spondylitis often starts around the sacroiliac joints, where the sacrum (the lowest major part of the spine) joins the ilium bone of the pelvis in the lower back region.
  • Bony fusion -- Ankylosing spondylitis can cause an overgrowth of the bones, which may lead to abnormal joining of bones, called "bony fusion." Fusion affecting bones of the neck, back, or hips may impair a person's ability to perform routine activities. Fusion of the ribs to the spine or breastbone may limit a person's ability to expand his or her chest when taking a deep breath.
  • Pain in ligaments and tendons -- Spondylitis also may affect some of the ligaments and tendons that attach to bones. Tendonitis (inflammation of the tendon) may cause pain and stiffness in the area behind or beneath the heel, such as the Achilles tendon at the back of the ankle.

SOURCES:

Spondylitis Association of America.

WebMD Health News: "FDA Approves Cymbalta for Chronic Musculoskeletal Pain."

FDA. “FDA approves Inflectra, a biosimilar to Remicade.” "FDA approves Amjevita, a biosimilar to Humira.”

Reviewed by Tyler Wheeler on December 28, 2018

SOURCES:

Spondylitis Association of America.

WebMD Health News: "FDA Approves Cymbalta for Chronic Musculoskeletal Pain."

FDA. “FDA approves Inflectra, a biosimilar to Remicade.” "FDA approves Amjevita, a biosimilar to Humira.”

Reviewed by Tyler Wheeler on December 28, 2018

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What causes ankylosing spondylitis?

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