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How do you treat a mixed bipolar episode?

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Manic or depressive episodes with mixed features generally require treatment with medication, but they're more difficult to control than an episode of pure mania or depression. Mood stabilizers (particularly Depakote), as well as atypical antipsychotic drugs, are considered the first-line treatments.

Common antidepressants have been shown to make mania symptoms worse without necessarily improving depressive symptoms, so most experts say not to use them.

ECT can be helpful if medication fails or can't be used.

SOURCES: National Institute of Mental Health web site, "Bipolar Disorder." Benazzi, F. March 17, 2007. Mick, E. 2003. McElroy, S. January 1997. McElroy, S. December 1992. Medical News Today: "Study Identifies Predictors of Bipolar Disorder Risk." WebMD Medical Reference from Healthwise: "Bipolar Disorder: What Increases Your Risk." Moore, D. and Jefferson, J. , Mosby, 2004. Goodwin, F. Sept. 17, 2003. Conway, K. February 2006. Medscape Psychiatry & Mental Health: "Substance Abuse and Bipolar Disorder."










Lancet,Journal of Child and Adolescent Psychopharmacology,American Journal of Psychiatry,American Journal of Psychiatry,Handbook of Medical PsychiatryThe Journal of the American Medical Association,Journal of Clinical Psychiatry,

Reviewed by Smitha Bhandari on June 20, 2019

SOURCES: National Institute of Mental Health web site, "Bipolar Disorder." Benazzi, F. March 17, 2007. Mick, E. 2003. McElroy, S. January 1997. McElroy, S. December 1992. Medical News Today: "Study Identifies Predictors of Bipolar Disorder Risk." WebMD Medical Reference from Healthwise: "Bipolar Disorder: What Increases Your Risk." Moore, D. and Jefferson, J. , Mosby, 2004. Goodwin, F. Sept. 17, 2003. Conway, K. February 2006. Medscape Psychiatry & Mental Health: "Substance Abuse and Bipolar Disorder."










Lancet,Journal of Child and Adolescent Psychopharmacology,American Journal of Psychiatry,American Journal of Psychiatry,Handbook of Medical PsychiatryThe Journal of the American Medical Association,Journal of Clinical Psychiatry,

Reviewed by Smitha Bhandari on June 20, 2019

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How are antipsychotics used for mixed features of bipolar episode?

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