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What are the risks of mixed features during mood episodes of bipolar disorder?

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The most serious risk of mixed features during a manic or depressive episode is suicide. People with bipolar disorder are 10 to 20 times more likely to commit suicide than people without bipolar disorder. Tragically, as many as 10% to 15% of people with bipolar disorder eventually lose their lives to suicide.

Evidence shows that during episodes with mixed features, people may be at even higher risk for suicide than people in episodes of bipolar depression.

Treatment reduces the likelihood of serious depression and suicide. Lithium in particular, taken long term, may lessen the risk of suicide.

People with bipolar disorder are also at higher risk for substance abuse. Nearly 60% of people with bipolar disorder abuse drugs or alcohol. Substance abuse is associated with more severe or poorly controlled bipolar disorder.

SOURCES: National Institute of Mental Health web site, "Bipolar Disorder." Benazzi, F. March 17, 2007. Mick, E. 2003. McElroy, S. January 1997. McElroy, S. December 1992. Medical News Today: "Study Identifies Predictors of Bipolar Disorder Risk." WebMD Medical Reference from Healthwise: "Bipolar Disorder: What Increases Your Risk." Moore, D. and Jefferson, J. , Mosby, 2004. Goodwin, F. Sept. 17, 2003. Conway, K. February 2006. Medscape Psychiatry & Mental Health: "Substance Abuse and Bipolar Disorder."










Lancet,Journal of Child and Adolescent Psychopharmacology,American Journal of Psychiatry,American Journal of Psychiatry,Handbook of Medical PsychiatryThe Journal of the American Medical Association,Journal of Clinical Psychiatry,

Reviewed by Smitha Bhandari on June 11, 2017

SOURCES: National Institute of Mental Health web site, "Bipolar Disorder." Benazzi, F. March 17, 2007. Mick, E. 2003. McElroy, S. January 1997. McElroy, S. December 1992. Medical News Today: "Study Identifies Predictors of Bipolar Disorder Risk." WebMD Medical Reference from Healthwise: "Bipolar Disorder: What Increases Your Risk." Moore, D. and Jefferson, J. , Mosby, 2004. Goodwin, F. Sept. 17, 2003. Conway, K. February 2006. Medscape Psychiatry & Mental Health: "Substance Abuse and Bipolar Disorder."










Lancet,Journal of Child and Adolescent Psychopharmacology,American Journal of Psychiatry,American Journal of Psychiatry,Handbook of Medical PsychiatryThe Journal of the American Medical Association,Journal of Clinical Psychiatry,

Reviewed by Smitha Bhandari on June 11, 2017

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How are mood stabilizers used for mixed features of bipolar episode?

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