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What is the treatment for depression in mixed bipolar disorder?

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Common antidepressants such as fluoxetine (Prozac), sertraline (Zoloft), and paroxetine (Paxil) have been shown to make mania symptoms worse without necessarily improving depressive symptoms when they happen at the same time. So most experts say not to use antidepressants during episodes with mixed features. Mood stabilizers (particularly Depakote), as well as atypical antipsychotic drugs, are considered the first-line treatments for mood episodes with mixed features.

Bipolar disorder usually involves recurrences of mixed, manic, or depressed phases of illness. Therefore, it is usually recommended that medications be continued in an ongoing fashion after an acute episode is over. This prevents relapses and is sometimes called maintenance treatment.

SOURCES: National Institute of Mental Health web site, "Bipolar Disorder." Benazzi, F. March 17, 2007. Mick, E. 2003. McElroy, S. January 1997. McElroy, S. December 1992. Medical News Today: "Study Identifies Predictors of Bipolar Disorder Risk." WebMD Medical Reference from Healthwise: "Bipolar Disorder: What Increases Your Risk." Moore, D. and Jefferson, J. , Mosby, 2004. Goodwin, F. Sept. 17, 2003. Conway, K. February 2006. Medscape Psychiatry & Mental Health: "Substance Abuse and Bipolar Disorder."










Lancet,Journal of Child and Adolescent Psychopharmacology,American Journal of Psychiatry,American Journal of Psychiatry,Handbook of Medical PsychiatryThe Journal of the American Medical Association,Journal of Clinical Psychiatry,

Reviewed by Smitha Bhandari on June 11, 2017

SOURCES: National Institute of Mental Health web site, "Bipolar Disorder." Benazzi, F. March 17, 2007. Mick, E. 2003. McElroy, S. January 1997. McElroy, S. December 1992. Medical News Today: "Study Identifies Predictors of Bipolar Disorder Risk." WebMD Medical Reference from Healthwise: "Bipolar Disorder: What Increases Your Risk." Moore, D. and Jefferson, J. , Mosby, 2004. Goodwin, F. Sept. 17, 2003. Conway, K. February 2006. Medscape Psychiatry & Mental Health: "Substance Abuse and Bipolar Disorder."










Lancet,Journal of Child and Adolescent Psychopharmacology,American Journal of Psychiatry,American Journal of Psychiatry,Handbook of Medical PsychiatryThe Journal of the American Medical Association,Journal of Clinical Psychiatry,

Reviewed by Smitha Bhandari on June 11, 2017

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What is a rapid cycling pattern in bipolar disorder?

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