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What's the link between valproic acid and PCOS?

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In rare cases, valproic acid may raise levels of the male hormone testosterone and lead to polycystic ovary syndrome (PCOS). PCOS is a condition that affects the ovaries and leads to obesity, excess body hair, and irregular menstrual cycles. Girls and young women who are taking valproic acid should see their doctors regularly to check on this risk.

From: Women With Bipolar Disorder WebMD Medical Reference

SOURCES:

National Institute of Mental Health: "Bipolar Disorder."

Cornell University: "Manic Depression / Bipolar Disorder."

Isimaru-Tseng, T.V. J 2000; vol 59: pp 51-53. Hawaii Med

Blehar, M.C. 1998; vol 34: pp 239-243. Psychopharmacol Bull,

University of Hawaii System: "Mental Illness and Menopause:

A Patient and Family Perspective."

Freeman, M.P. , 2002; vol 63: pp 284-287. J Clin Psychiatry

National Alliance on Mental Illness: "Managing Pregnancy and Bipolar Disorder."

FDA Drug Safety Communication.

Reviewed by Joseph Goldberg on April 6, 2019

SOURCES:

National Institute of Mental Health: "Bipolar Disorder."

Cornell University: "Manic Depression / Bipolar Disorder."

Isimaru-Tseng, T.V. J 2000; vol 59: pp 51-53. Hawaii Med

Blehar, M.C. 1998; vol 34: pp 239-243. Psychopharmacol Bull,

University of Hawaii System: "Mental Illness and Menopause:

A Patient and Family Perspective."

Freeman, M.P. , 2002; vol 63: pp 284-287. J Clin Psychiatry

National Alliance on Mental Illness: "Managing Pregnancy and Bipolar Disorder."

FDA Drug Safety Communication.

Reviewed by Joseph Goldberg on April 6, 2019

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