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    Finding the Right Autism Treatment

    Early, intense therapy works, but hundreds of other treatments being used are untested.

    Drug Treatments for Autism continued...

    Spurred by huge numbers of parents giving secretin to their ASD kids, researchers rushed to study the drugs effects.

    "Secretin is right now the best-studied drug in autism," Scahill says. "There have been 12 or 13 placebo-controlled trials, but not one showed secretin to be better than placebo. Researchers spent vast amounts of time and money on it and we don't have a lot to show for it. That is an example of how it shouldn't go."

    Chelation for Autism

    Although most researchers do not think so, many parents are struck by similarities between some of the symptoms of mercury poisoning and autism. Some of these parents seek chelation therapy for their children, which uses a chemical that helps the body eliminate heavy metals.

    Hyman notes that there is no evidence that removing heavy metals from the body undoes damage caused by heavy-metal poisoning. But many parents believe their children's ASD symptoms improved after the treatment.

    Swedo and colleagues at the NIMH have designed a clinical trial to test this treatment, but the study is in limbo as the NIMH review board feels the known risks of the treatment outweigh the evidence that it might work. Meanwhile, Swedo says, a group of practitioners called Defeat Autism Now, which promotes chelation and other complementary/alternative autism treatments, is completing a study of the treatment.

    Most of the researchers who spoke with WebMD for this article expressed the opinion that chelation is both ineffective for autism and dangerous; none advise parents to try it.

    Gluten-Free Casien-Free (GFCF) Diet for Autism

    Many parents of children with autism believe that their children suffer from an inability to digest wheat and/or dairy products. Some who have put their children on gluten-free/casien-free diets report seeing remarkable changes in their children's behavior.

    This GFCF diet has become one of the most commonly used treatments for autism, despite concerns that ASD kids -- who tend to be very picky eaters -- may become undernourished by following a GFCF diet.

    A highly regarded 1995 study suggested that ASD kids on a GFCF diet for one year had fewer autistic traits. However, preliminary results from a randomized, controlled clinical trial did not show a benefit.

    More rigorous randomized, placebo-controlled clinical trials of the GFCF diet -- including one by Hyman -- are under way.

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