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What the Nose Knows May Affect Your Brain Health

woman smelling rose

How well you can smell could be a sign of overall brain health.

A growing body of research suggests that the two are strongly linked, though researchers are just starting to figure out how and why.

In a recent study, researchers found that a simple smell test may predict your chance of having dementia.

“Ability to smell is a window into parts of the brain related to core functions, like pleasure, emotion, and memory,” says Jayant Pinto, MD, author of the study and an otolaryngologist and head and neck surgeon at University of Chicago Medicine. The smell test, he adds, allows doctors “to see, a little earlier, a sign that problems are happening.”

In the study, researchers visited the homes of more than 2,900 adults ages 57 to 85 to test how well they could recognize five different odors: peppermint, fish, orange, rose, and leather. Five years later, researchers followed up with the older adults to find out if any of them had gotten a diagnosis of dementia since taking the smell test.

Those who couldn’t identify at least four of the five odors on the test were twice as likely as others to have dementia 5 years later.

The lower their score on the smell test, the greater their odds of having dementia. This decline in memory and thinking skills comes in several forms, including Alzheimer’s disease, Parkinson’s, and Lewy body dementia, among others. 

Pinto’s is not the only study to link a waning sense of smell -- also known as olfactory function -- with the breakdown of other parts of the brain. In fact, it happens with many conditions, known as neurodegenerative diseases, in which brain health declines over time. Obesity, which can raise you odds of having Alzheimer’s and Parkinson’s disease, might also dull the sense of smell. Studies show that exercise lowers the chance of losing this sense. But what is the connection between how well you detect and identify smells and your overall health? Doctors and scientists are trying to sniff out the answer to this crucial question.

The Nose Is a Window to the Brain

Your nose may provide a direct path for harmful substances from the environment to reach your brain. “Your olfactory nerve is sitting out there sampling air,” says Pinto. “That’s what it’s supposed to do, but it’s at risk for viruses, bacteria, whatever’s in your nose.”

That’s especially risky since cells in the nose transmit directly to the brain. Neurons capture odors and send signals to the smell center at the base of the brain, known as the olfactory bulb. The signals then go to different areas throughout the brain, says Marie-Elyse Lafaille-Magnan, who researches the link between the sense of smell and the odds of Alzheimer’s at McGill University in Montreal.

Some of the areas the olfactory bulb transmits signals to are related to thinking and memory. 

In fact, on autopsy, researchers have found brain tangles associated with Alzheimer’s disease, known as tau, in the olfactory bulbs of people who had Alzheimer’s, Parkinson’s, and other forms of dementia linked to smell loss.

The nose’s direct line from the environment to the brain could mean that pollutants, viruses, and bacteria travel through the nasal passages to set the wheels of brain disease in motion. Some viruses, which researchers consider a possible cause of Parkinson’s disease, could reach the brain through the nose. Studies show that children and young adults who live in areas with heavy air pollution, such as Mexico City, have brain inflammation and buildup in their brains of some of the same proteins seen in older adults who have Alzheimer’s or Parkinson’s. 

These tiny particles that get into the brain through the nose may actually start the disease process, says Richard Doty, PhD, director of the Smell and Taste Center at the University of Pennsylvania Perelman School of Medicine.

It has already been shown that people who carry the APOE e4 gene mutation have a higher chance of getting Alzheimer’s. And notably, this study suggests that these people have an even higher chance of Alzheimer’s if they also live in a highly polluted area.

Maybe it’s because the nose is so likely to be invaded by viruses and bacteria that olfactory cells can regenerate, even into old age, constantly repairing the sense of smell. “It’s possible that when that regenerative process peters out, when we get older, it’s a sign that [brain cells] can’t regenerate, and that reflects what’s going on centrally,” says Pinto. 

That petering out of both sense of smell and thinking skills associated with dementia might result from damage to a single part of the brain called the basal nucleus of Meynert. This damage could be due to harmful substances reaching the brain through the nose, or it could be an unrelated process.

Doty’s research found a strong connection between low scores on a 40-item smell test and damage to this area of the brain. His recent article in The Lancet outlines possible ways that sense of smell and overall brain health could be linked and “may be the genesis of many neurodegenerative diseases.”

A nose that doesn’t work so well gives the brain less information. Some research suggests that this lack of stimulation may weaken other systems.

“As your hearing declines, as your vision declines, as your sense of smell declines, you’re getting less information,” Pinto says. The circuits that usually bring this information in, he adds, might then stop working as well, which can lead to problems elsewhere in the brain. “Call it the ‘sensory deprivation hypothesis.’ ”

Weight seems to play a role, too. Obesity is known to make brain disease more likely. People who are obese might have a weaker sense of smell than others. Researchers suggest that one possible explanation is that adipokines, chemicals given off by fat tissue, could weaken the sense of smell.

The relationship could also be indirect. Weight gain can lead to diabetes and heart disease, which hurt blood flow, including to the brain, says Pinto. “We know that vascular disease is a risk factor for dementia. So that is one way that all these things could be linked.”

Regular exercise, which improves blood flow and burns fat, helps the sense of smell in older adults, according to research.

What’s in a Test?

Although a smell test can tip doctors off that something serious might be going on, it’s not a tool for diagnosis. While the test does a very good job of identifying the type of smell loss that can lead to brain diseases, the results won’t suggest a person has one condition rather than another. But the results could prompt doctors to investigate more. There’s not yet a cure for Alzheimer’s, no matter how early it’s detected, but there’s value in knowing.

First, finding people who are more likely to have dementia but don’t yet show symptoms could direct more people to clinical trials to find treatments to slow the progress towards Alzheimer’s.

“Maybe one reason these trials aren’t working is because we’re getting people in which the disease has already manifested, so it’s too late,” says Pinto.

In the 5 to 10 years between the loss of smell and possible signs of dementia, lifestyle changes -- such as exercise, more social interaction, and brain stimulation through puzzles -- might make a difference, Pinto adds. Earlier detection can also help families and caregivers prepare. 

But before you go trying to sniff out your own risk for dementia, don’t be alarmed. Not everyone who loses some sense of smell goes on to develop dementia. “As we go through life, the smell ability diminishes,” says Doty. “Between the ages of 65 and 80, half the population has smell loss. After 85, three-quarters do.” 

What’s more, while you might think you’re losing your sense of smell, you probably aren’t. “Self-perceived sense of smell doesn’t correlate well with objective sense of smell,” says Pinto.

Still, Pinto hopes to see the sense of smell get a little more attention in preventive care. “It has really important relationships with overall health, and we ought to test more people for it.”

WebMD Article Reviewed by Melinda Ratini, DO, MS on October 11, 2017

Sources

Jayant Pinto, MD, associate professor of surgery, University of Chicago Medicine.

Richard Doty, PhD, Director, Smell and Taste Center, Perelman School of Medicine, University of Pennsylvania.

Marie-Elyse Lafaille-Magnan, PhD candidate, McGill University, Montreal.

D.P. Devanand, MD, professor of psychiatry and neurology, director of geriatric psychiatry, Columbia University Medical Center.

Carla R. Schubert, researcher, EpiSense Research Program, department of ophthalmology & visual sciences, School of Medicine and Public Health, University of Wisconsin.

Journal of the American Geriatrics Society: “Olfactory Dysfunction Predicts Subsequent Dementia in Older U.S. Adults.”

JAMA Otolaryngology -- Head and Neck Surgery: “Exercise Is Associated with Lower Long-Term Risk of Olfactory Impairment in Older Adults.”

The Lancet Neurology: “Olfactory dysfunction in neurodegenerative diseases: Is there a common pathological substrate?”

Learning and memory: “Acetylcholine and Olfactory Perceptual Learning.”

Toxicologic Pathology: “Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood-brain barrier, ultrafine particulate deposition, and accumulation of amyloid beta-42 and alpha-synuclein in children and young adults.”

Neurotoxicity Research: “Dysfunctional Sensory Modalities, Locus Coeruleus, and Basal Forebrain: Early Determinants that Promote Neuropathogenesis of Cognitive and Memory Decline and Alzheimer’s Disease.”

PLoS One: “An increase in visceral fat is associated with a decrease in the taste and olfactory capacity.”

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