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How is progressive multifocal leukoencephalopathy (PML) linked to multiple sclerosis (MS) and Crohn's disease?

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PML has been linked to the drug natalizumab (Tysabri), which is used to treat multiple sclerosis (MS) and Crohn's disease. People with MS or Crohn's disease may be tested for the JC virus before they start this medication or others like it. If you're a carrier of the virus, you might still be able to take the drugs, butmake sure you discuss the risks and benefits with your doctor first.

People with MS and Crohn's disease who develop PML often have to stop taking the drugs. They also may need a procedure called plasma exchange to clear out the medication.

From: What Is the JC Virus? WebMD Medical Reference

SOURCES:

American Association for Clinical Chemistry: "JC Virus: What Is It, and How Should I Test for It?"

American Journal of Neuroradiology: "JC Virus Infection of the Brain."

Journal of Virology: published online December 2010. Progressive multifocal leukoencephalopathy in a patient without apparent immunosuppression,

Merck Manual: "Progressive Multifocal Leukoencephalopathy (PML)."

Multiple Sclerosis Trust: "JC virus."

National Institutes of Health, AIDS Info: "Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents."

National Institute of Neurological Disorders and Stroke: "NINDS Progressive Multifocal Leukoencephalopathy Information Page."

Reviewed by Laura J. Martin on July 10, 2018

SOURCES:

American Association for Clinical Chemistry: "JC Virus: What Is It, and How Should I Test for It?"

American Journal of Neuroradiology: "JC Virus Infection of the Brain."

Journal of Virology: published online December 2010. Progressive multifocal leukoencephalopathy in a patient without apparent immunosuppression,

Merck Manual: "Progressive Multifocal Leukoencephalopathy (PML)."

Multiple Sclerosis Trust: "JC virus."

National Institutes of Health, AIDS Info: "Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents."

National Institute of Neurological Disorders and Stroke: "NINDS Progressive Multifocal Leukoencephalopathy Information Page."

Reviewed by Laura J. Martin on July 10, 2018

NEXT QUESTION:

How can people with HIV prevent progressive multifocal leukoencephalopathy (PML)?

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