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What other prescription and over-the-counter drugs can lead to serotonin syndrome?

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Other prescription and over-the-counter drugs that can raise serotonin levels alone or in combination to cause serotonin syndrome include:

  • Serotonin and norepinephrine reuptake inhibitors (SNRIs), a class of antidepressants including desvenlafaxine (Khedezla), desvenlafaxine succinate (Pristiq), duloxetine (Cymbalta), levomilnacipran (Fetzima), and venlafaxine (Effexor).
  • Monoamine oxidase inhibitors (MAOIs), a class of antidepressants including isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), and transdermal selegiline (EMSAM)
  • Buspirone (BuSpar), a drug used to treat anxiety disorders
  • Desyrel (Trazodone), a drug prescribed for depression or insomnia
  • Migraine treatments such as almotriptan (Axert), Amerge (naratriptan), rizatriptan (Maxalt), sumatriptan (Imitrex), and zolmitriptan (Zomig)
  • Certain pain medications, including fentanyl (Sublimaze, Fentora), fentanyl citrate (Actiq), meperidine (Demerol), pentazocine (Talwin), and tramadol (Ultram)
  • Dextromethorphan , a cough suppressant found in many over-the-counter and prescription cough medicines or cold medicines
  • Certain medications prescribed for nausea, such as granisetron (Kytril), metoclopramide (Reglan), and ondansetron (Zofran)
  • Antidepressants that affect multiple serotonin receptors, such as vortioxetine (Trintellix -formerly Brintellix) and vilazodone (Viibryd)

From: What Is Serotonin Syndrome? WebMD Medical Reference

SOURCES: 

American Headache Society: "What is Serotonin Syndrome and What Should You Know About It?"

National Cancer Institute: "Serotonin." OhioHealthOnline: "Serotonin Syndrome." MedlinePlus: "Serotonin Syndrome." Agency for Healthcare Research and Quality: "New report finds little evidence to determine the usefulness of genetic tests in the treatment of depression." Boyer, E. , March 17, 2005.



New England Journal of Medicine

Reviewed by Joseph Goldberg on February 9, 2017

SOURCES: 

American Headache Society: "What is Serotonin Syndrome and What Should You Know About It?"

National Cancer Institute: "Serotonin." OhioHealthOnline: "Serotonin Syndrome." MedlinePlus: "Serotonin Syndrome." Agency for Healthcare Research and Quality: "New report finds little evidence to determine the usefulness of genetic tests in the treatment of depression." Boyer, E. , March 17, 2005.



New England Journal of Medicine

Reviewed by Joseph Goldberg on February 9, 2017

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