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What role do supplements and illegal drugs play in serotonin syndrome?

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Some illegal drugs, such as LSD and cocaine, and dietary supplements, including St. John's wort and ginseng, can lead to serotonin syndrome when combined with antidepressants that affect serotonin.

The FDA recently asked drug manufacturers to include warning labels on their products to let patients know about the potential risk of serotonin syndrome. If you are uncertain about drugs you take or have been prescribed, check the label or speak with your doctor. Don't stop any medication before talking to your doctor.

SOURCES: 

American Headache Society: "What is Serotonin Syndrome and What Should You Know About It?"

National Cancer Institute: "Serotonin."
OhioHealthOnline: "Serotonin Syndrome."
MedlinePlus: "Serotonin Syndrome."
Agency for Healthcare Research and Quality: "New report finds little evidence to determine the usefulness of genetic tests in the treatment of depression."
Boyer, E. New England Journal of Medicine, March 17, 2005.

Reviewed by Jennifer Casarella on March 2, 2020

SOURCES: 

American Headache Society: "What is Serotonin Syndrome and What Should You Know About It?"

National Cancer Institute: "Serotonin."
OhioHealthOnline: "Serotonin Syndrome."
MedlinePlus: "Serotonin Syndrome."
Agency for Healthcare Research and Quality: "New report finds little evidence to determine the usefulness of genetic tests in the treatment of depression."
Boyer, E. New England Journal of Medicine, March 17, 2005.

Reviewed by Jennifer Casarella on March 2, 2020

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How do you diagnose serotonin syndrome?

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