Breast Cancer Recurrence

When breast cancer comes back after treatment and a period of time when it was thought to be gone, it's called recurrence. Only a few cancer cells need to survive treatment for this to happen. Over time, they can multiply enough to cause problems and be found.

Breast cancer can come back at any time, but most recurrences happen in the first 5 years after treatment. Chances of recurrence are highest during the first 2 years after treatment.

Breast cancer can come back as a local recurrence (meaning in the treated breast or near the mastectomy scar) or somewhere else in the body. Some of the most common places of recurrence outside the breast are the lymph nodes, bones, liverlungs, and brain.

How Do You Know?

Keep doing breast self-exams, checking the treated area and your other breast each month. Tell your doctor about any changes right away.

Also, keep getting regular mammograms. In some screening centers, three-dimensional mammograms are available in addition to traditional digital mammograms. If gene tests show that you have changes to the BRCA genes, you may also need an MRI of your breast. Talk to your doctor about the best screening tests for you.

Breast changes that might be recurrence include:

  • A lump or thickening in or near the breast or in the underarm that doesn’t go away after your period
  • A change in the size, shape, or contour of the breast
  • A marble-like area under the skin
  • A change in the feel or look of the skin on the breast or nipple, including skin that is dimpled, puckered, scaly, red, warm, or swollen
  • Blood or clear fluid coming out of a nipple

Other common signs of recurrence include:

See your doctor right away if you have signs that might mean that your cancer has spread to other parts of your body. Symptoms of breast cancer spread include:

  • Trouble breathing or coughs that won’t go away
  • Persistent pain in your bones and anywhere on your body
  • Lack of appetite
  • Seizures
  • Jaundice (yellow skin or eyes)

Along with monthly self-exams, you should have follow-up appointments with your doctor. They should examine your breasts, ask about any symptoms, and order lab or imaging tests if needed. Tell them right away about any new symptoms.

At first, your follow-up appointments may be every 3 to 4 months. The longer you are cancer-free, the less often you will need to see your doctor.


What Makes It More Likely

There’s no sure way to know whether breast cancer will come back, and there’s no sure way to keep it from coming back. Things that raise the odds include:

  • Tumor size. The larger the tumor was, the higher the chance of recurrence.
  • Cancer spread. If your breast cancer had spread to your lymph nodes, the more lymph nodes that had cancer cells, the more likely your risk of recurrence. Your risk is also higher if cancer cells were found in the lymph vessels or blood vessels of your breast.
  • Hormone receptors . About two-thirds of all breast cancers have receptors for estrogen (called ER+) or progesterone (PR+) or both types.
  • HER2 . This gene triggers the growth of cancer cells.
  • Histologic grade. This term refers to how much the tumor cells resemble normal cells when viewed under the microscope. The higher the histologic grade, the higher the odds of recurrence.
  • Nuclear grade. This is the rate at which cancer cells in the tumor divide to form more cells. Cancer cells with a high nuclear grade are usually more aggressive (faster growing).


Tests can tell your doctor what’s going on. They may be the same ones you had the first time you were diagnosed, such as mammograms, CT scans, MRIs, PET scans, and bone scans. The type of test used depends on where the cancer might be. Imaging tests will show exactly where it is and how far it has spread.

Many times, a biopsy is needed to know what kind of cancer it is. It may be breast cancer that’s come back, or it may be a new kind of cancer. (It’s rare, but you can have two different kinds of cancer.) This is key information when making treatment plans and talking about outcomes.


The type of treatment you get for local breast cancer recurrence depends on what you got at first. If you had a lumpectomy, local recurrence is usually treated with a mastectomy. If you had a mastectomy, recurrence near the mastectomy site is treated by removing the tumor if possible, usually followed by radiation.


In either case, you may have hormone therapy, chemotherapy, or radiation after surgery. Sometimes, your doctor will use a combination.

If breast cancer is found in the other breast, it may be a new tumor unrelated to the first breast cancer. This would be treated like a new case of breast cancer. You would get either a lumpectomy or mastectomy, followed by more treatments if necessary.

If the cancer comes back in another part of your body, such as the bones, lungs, liver, or brain, you may get surgery, chemotherapy, radiation, hormone therapy, targeted therapy, or a combination. It depends on your situation.

Doctors may recommend that women whose cancer cells have high levels of the HER2 protein get targeted therapy, alone or with chemotherapy, with one of these drugs:

Immunotherapy triggers your immune system to find and destroy cancer cells. Atezolizumab (Tecentriq) is an immunotherapy drug used in combination with the chemotherapy drug paclitaxel (Abraxane) to block a protein called PD-L1.  This treatment can be given to women with a certain type of advanced breast cancer.

How Do I Deal With a Recurrence?

This diagnosis may be emotionally harder to deal with than the first one. You did your part, and the cancer was gone. It’s not fair to have to go through it all again. You may think you got the wrong treatment last time or did something wrong. You may be angry with your doctor. You may think you can’t do this again. You may feel scared about what might happen. Many people feel this way.

Some people find that they’re able to handle the news of a recurring cancer better than they did the first diagnosis. You may feel stronger than the first time and certainly know more than you did before.

If you have depression and anxiety, these conditions usually improve with treatment. It may help for you to confide in your loved ones. Talk to your doctor about your concerns. Get the information and help you need to move forward. That may let you feel more empowered.

WebMD Medical Reference Reviewed by Neha Pathak, MD on February 08, 2021



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