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How is the FISH test used to diagnosed HER2-positive breast cancer?

ANSWER

The FISH test uses fluorescent pieces of DNA that stick to the HER2 gene in cells, which can then be counted under a microscope.

SOURCES:

UpToDate.

Breastcancer.org: "HER2 Status," "How Triple-Negative Breast Cancer Behaves and Looks,” “Inform HER2 Dual ISH Test,”  “SPoTLight HER2 CISH Test.”

Lab Tests Online: "HER-2/neu."

American Cancer Society: "How is breast cancer diagnosed?" "Treatment of invasive breast cancer, by stage,” “Understanding Your Pathology Report: Breast Cancer,” "Signs and Symptoms of Breast Cancer."

Ithimakin, S. Cancer Research, April 1, 2013.

Reviewed by Laura J. Martin on December 21, 2020

SOURCES:

UpToDate.

Breastcancer.org: "HER2 Status," "How Triple-Negative Breast Cancer Behaves and Looks,” “Inform HER2 Dual ISH Test,”  “SPoTLight HER2 CISH Test.”

Lab Tests Online: "HER-2/neu."

American Cancer Society: "How is breast cancer diagnosed?" "Treatment of invasive breast cancer, by stage,” “Understanding Your Pathology Report: Breast Cancer,” "Signs and Symptoms of Breast Cancer."

Ithimakin, S. Cancer Research, April 1, 2013.

Reviewed by Laura J. Martin on December 21, 2020

NEXT QUESTION:

When might you need more tests to diagnose HER2-positive breast cancer?

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