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How is the IHC test used to diagnose HER2-positive breast cancer?

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The IHC test uses certain antibodies that identify the HER2 protein in a sample of breast cancer tissue. If there is a lot of it, the cells change color in the sample.

SOURCES:

UpToDate.

Breastcancer.org: "HER2 Status," "How Triple-Negative Breast Cancer Behaves and Looks,” “Inform HER2 Dual ISH Test,”  “SPoTLight HER2 CISH Test.”

Lab Tests Online: "HER-2/neu."

American Cancer Society: "How is breast cancer diagnosed?" "Treatment of invasive breast cancer, by stage,” “Understanding Your Pathology Report: Breast Cancer,” "Signs and Symptoms of Breast Cancer."

Ithimakin, S. Cancer Research, April 1, 2013.

Reviewed by Laura J. Martin on December 21, 2020

SOURCES:

UpToDate.

Breastcancer.org: "HER2 Status," "How Triple-Negative Breast Cancer Behaves and Looks,” “Inform HER2 Dual ISH Test,”  “SPoTLight HER2 CISH Test.”

Lab Tests Online: "HER-2/neu."

American Cancer Society: "How is breast cancer diagnosed?" "Treatment of invasive breast cancer, by stage,” “Understanding Your Pathology Report: Breast Cancer,” "Signs and Symptoms of Breast Cancer."

Ithimakin, S. Cancer Research, April 1, 2013.

Reviewed by Laura J. Martin on December 21, 2020

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How is the FISH test used to diagnosed HER2-positive breast cancer?

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