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What does a positive FISH test for HER2 breast cancer mean?

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FISH testing usually returns one of two results: positive or negative.

Positive means your breast cancer cells make too much HER2 and your doctor should treat you with drugs that target that protein.

Sometimes FISH test results are unclear. If this happens, your doctor may do more tests to try to get a clear answer about your HER2 protein levels.

SOURCES:

Cancer.Net: “Breast Cancer: Introduction,” “Breast Cancer: Diagnosis.”

Methods in Molecular Biology: “Fluorescence in situ hybridization of cells, chromosomes, and formalin-fixed paraffin-embedded tissues.”

MedlinePlus: “HER2 (Breast Cancer) Testing.”

Journal of Pathology and Translational Medicine: “HER2 status in breast cancer: Changes in guidelines and complicating factors for interpretation.”

American Cancer Society: “Targeted Therapy for Breast Cancer.”

Cancer.Net: “ASCO Answers: Breast Cancer.”

American Cancer Society: “Surgical Breast Biopsy,” “Breast Biopsy.”

Lab Tests Online: “HER2.”

BreastCancer.Org: “FISH Test (Fluorescence In Situ Hybridization).”

Reviewed by Melinda Ratini on May 27, 2020

SOURCES:

Cancer.Net: “Breast Cancer: Introduction,” “Breast Cancer: Diagnosis.”

Methods in Molecular Biology: “Fluorescence in situ hybridization of cells, chromosomes, and formalin-fixed paraffin-embedded tissues.”

MedlinePlus: “HER2 (Breast Cancer) Testing.”

Journal of Pathology and Translational Medicine: “HER2 status in breast cancer: Changes in guidelines and complicating factors for interpretation.”

American Cancer Society: “Targeted Therapy for Breast Cancer.”

Cancer.Net: “ASCO Answers: Breast Cancer.”

American Cancer Society: “Surgical Breast Biopsy,” “Breast Biopsy.”

Lab Tests Online: “HER2.”

BreastCancer.Org: “FISH Test (Fluorescence In Situ Hybridization).”

Reviewed by Melinda Ratini on May 27, 2020

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