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How can immunotherapy drugs treat metastatic bladder cancer?

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Your immune fights infection and diseases, including cancer. But cancer cells can avoid your body’s defenses.

Immunotherapy drugs work by making cancer cells easier targets or by boosting the immune system to make it more effective against the disease.

SOURCES:

National Cancer Institute: “FDA Approves New Immunotherapy Drug for Bladder Cancer,” “Immunotherapy.”

Memorial Sloan Kettering Cancer Center: “Immunotherapy,” “FDA Approves ‘Game Changer’ Immunotherapy Drug for Bladder Cancer,” “A Phase II Study Assessing Mediators of Response to Nivolumab and Ipilimumab Immunotherapy in Patients with Advanced Melanoma or Bladder Cancer,” A Phase I/IB Study of Immunotherapy with CPI-444 Alone and with Atezolizumab in Patients with Metastatic Solid Tumors.”

American Cancer Society: “FDA Approves New Immunotherapy Drug for Bladder Cancer,” “Immunotherapy for bladder cancer.”

The University of Texas MD Anderson Cancer Center: “Q&A Understanding Immunotherapy,” “Nivolumab immunotherapy helps patients with advanced bladder cancer,” “Immune checkpoint inhibitors shrink tumors in 26 to 38 percent of metastatic bladder cancer patients.”

American Society of Clinical Oncology: “Patients With Advanced Bladder Cancer Benefit From Anti-PD-L1 Immunotherapy.”

The Lancet: “Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial.”

FDA: “Nivolumab for Treatment of Urothelial Carcinoma.”

Reviewed by Laura J. Martin on March 3, 2019

SOURCES:

National Cancer Institute: “FDA Approves New Immunotherapy Drug for Bladder Cancer,” “Immunotherapy.”

Memorial Sloan Kettering Cancer Center: “Immunotherapy,” “FDA Approves ‘Game Changer’ Immunotherapy Drug for Bladder Cancer,” “A Phase II Study Assessing Mediators of Response to Nivolumab and Ipilimumab Immunotherapy in Patients with Advanced Melanoma or Bladder Cancer,” A Phase I/IB Study of Immunotherapy with CPI-444 Alone and with Atezolizumab in Patients with Metastatic Solid Tumors.”

American Cancer Society: “FDA Approves New Immunotherapy Drug for Bladder Cancer,” “Immunotherapy for bladder cancer.”

The University of Texas MD Anderson Cancer Center: “Q&A Understanding Immunotherapy,” “Nivolumab immunotherapy helps patients with advanced bladder cancer,” “Immune checkpoint inhibitors shrink tumors in 26 to 38 percent of metastatic bladder cancer patients.”

American Society of Clinical Oncology: “Patients With Advanced Bladder Cancer Benefit From Anti-PD-L1 Immunotherapy.”

The Lancet: “Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial.”

FDA: “Nivolumab for Treatment of Urothelial Carcinoma.”

Reviewed by Laura J. Martin on March 3, 2019

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