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What causes B-cell acute lymphoblastic leukemia?

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Most of the time, doctors don't know what causes B-cell acute lymphoblastic leukemia in children.

Some things make this disease more likely, including exposure to high doses of X-rays and other forms of radiation, or cancer treatment with chemotherapy. Children with certain genetic diseases, such as Down syndrome, are also more likely to get it.

SOURCES:

American Cancer Society: "How is childhood leukemia classified?" "Childhood Leukemia Overview," "High-dose chemotherapy and stem cell transplant for childhood leukemia."

Johns Hopkins Medicine: "Bone Marrow Biopsy."

Leukemia & Lymphoma Society: "Acute Lymphoblastic Leukemia."

Medscape: "Pediatric Acute Lymphoblastic Leukemia Clinical Presentation; History," "Background."

National Bone Marrow Donor Program: "Symptoms of ALL."

National Cancer Institute: "General Information About Childhood Acute Lymphoblastic Leukemia (ALL)," "Childhood Acute Lymphoblastic Leukemia Treatment PDQ."

National Institute of Allergy and Infectious Diseases: "B Cells," "Treatment Option Overview for Childhood ALL."

Woo, J. , June 2014. Experimental Hematology & Oncology

FDA: "FDA approval brings first gene therapy to the United States."

Reviewed by Laura J. Martin on June 27, 2018

SOURCES:

American Cancer Society: "How is childhood leukemia classified?" "Childhood Leukemia Overview," "High-dose chemotherapy and stem cell transplant for childhood leukemia."

Johns Hopkins Medicine: "Bone Marrow Biopsy."

Leukemia & Lymphoma Society: "Acute Lymphoblastic Leukemia."

Medscape: "Pediatric Acute Lymphoblastic Leukemia Clinical Presentation; History," "Background."

National Bone Marrow Donor Program: "Symptoms of ALL."

National Cancer Institute: "General Information About Childhood Acute Lymphoblastic Leukemia (ALL)," "Childhood Acute Lymphoblastic Leukemia Treatment PDQ."

National Institute of Allergy and Infectious Diseases: "B Cells," "Treatment Option Overview for Childhood ALL."

Woo, J. , June 2014. Experimental Hematology & Oncology

FDA: "FDA approval brings first gene therapy to the United States."

Reviewed by Laura J. Martin on June 27, 2018

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What are symptoms of B-cell acute lymphoblastic leukemia?

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