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What is acute promyelocytic leukemia (APL)?

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Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia, a cancer that affects stem cells. In APL, the leukemia cells contain special proteins that change the way your blood clots. Chemotherapy damages the leukemia cells and releases this protein, which can cause dangerous blood clots or severe bleeding.

SOURCES:

American Cancer Society: "Chemotherapy for Acute Myeloid Leukemia," "Other Drugs for Acute Myeloid Leukemia," "Radiation Therapy for Acute Myeloid Leukemia," "Stem Cell Transplant for Myeloid Leukemia," "Typical Treatment of Most Types of Acute Myeloid Leukemia (Except Acute Promyelocytic M3)."

American Society of Clinical Oncology: "Leukemia - Acute Myeloid - AML - Treatment Options."

National Cancer Institute: "Adult Acute Myeloid Leukemia Treatment (PDQ) - Patient Version."

UpToDate: "Patient education: Acute myeloid leukemia (AML) treatment in adults (Beyond the Basics)."

Reviewed by Laura J. Martin on November 29, 2017

SOURCES:

American Cancer Society: "Chemotherapy for Acute Myeloid Leukemia," "Other Drugs for Acute Myeloid Leukemia," "Radiation Therapy for Acute Myeloid Leukemia," "Stem Cell Transplant for Myeloid Leukemia," "Typical Treatment of Most Types of Acute Myeloid Leukemia (Except Acute Promyelocytic M3)."

American Society of Clinical Oncology: "Leukemia - Acute Myeloid - AML - Treatment Options."

National Cancer Institute: "Adult Acute Myeloid Leukemia Treatment (PDQ) - Patient Version."

UpToDate: "Patient education: Acute myeloid leukemia (AML) treatment in adults (Beyond the Basics)."

Reviewed by Laura J. Martin on November 29, 2017

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What is all-trans retinoic acid (ATRA) for acute promyelocytic leukemia (APL)?

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