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How does DNA damage lead to pancreatic cancer?

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No one knows exactly how the process of DNA damage leading to pancreatic cancer occurs. Analyzing pancreatic cancers removed by surgery shows certain mutations that occur in nearly all cases, and others that vary between people.

Some of these mutations occur randomly. Others occur in response to things we do or experience in the environment. Some mutations may be inherited. When enough mutations accumulate, a cell becomes malignant and a tumor begins to grow.

SOURCES:

Klein A.P. , July-August 2001; vol 7: pp 266-73. The Cancer Journal

Tersmette A.C. March 2001; vol 7: pp 738-44. Clinical Cancer Research,

Fuchs C.S. , Oct. 28, 1996; vol 156: pp 2255-60. Archives of Internal Medicine

Chari S.T. . January 2008; vol 134: pp 95-101. Gastroenterology

Michaud D.S. , Aug. 22-29, 2001; vol 286: pp 921-9. The Journal of the American Medical Association

Michaud D.S. , April 6, 2005; vol 97: pp 518-24. Journal of the National Cancer Institute

Reviewed by Minesh Khatri on July 24, 2017

SOURCES:

Klein A.P. , July-August 2001; vol 7: pp 266-73. The Cancer Journal

Tersmette A.C. March 2001; vol 7: pp 738-44. Clinical Cancer Research,

Fuchs C.S. , Oct. 28, 1996; vol 156: pp 2255-60. Archives of Internal Medicine

Chari S.T. . January 2008; vol 134: pp 95-101. Gastroenterology

Michaud D.S. , Aug. 22-29, 2001; vol 286: pp 921-9. The Journal of the American Medical Association

Michaud D.S. , April 6, 2005; vol 97: pp 518-24. Journal of the National Cancer Institute

Reviewed by Minesh Khatri on July 24, 2017

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What is the average risk for pancreatic cancer?

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