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How can targeted therapy help with treating gastroesophageal (GE) junction adenocarcinoma?

ANSWER

Targeted therapy uses special drugs that work against specific changes in cells that turn them into cancer. Some GE junction cancers have a protein called HER2 on the surfaces of their cells that helps them grow. These are called HER2-positive cancers. Trastuzumab (Herceptin) treats them by targeting the HER2 protein. Another targeted drug, ramucirumab (Cyramza), works against a protein called VEGF, which tumors need to make new blood vessels.

SOURCES:

American Cancer Society: "Key Statistics for Esophageal Cancer," "Living as an Esophagus Cancer Survivor," "Radiation Therapy for Esophageal Cancer," "Surgery for Esophageal Cancer," "Targeted Therapy for Esophageal Cancer," "Tests for Esophageal Cancer," "What is Cancer of the Esophagus?"

Annals of Thoracic Surgery : "The Society of Thoracic Surgeons guidelines on the diagnosis and staging of patients with esophageal cancer."

Cancer.Net: "Esophageal Cancer: Questions to Ask the Doctor."

Cancer Research UK: "About gastro oesophageal junction cancer," "Survival," "Treatment for gastro oesophageal junction cancer."

Cleveland Clinic: "Esophageal Cancer."

Johns Hopkins Medicine: "The Migration of Gastric Cancer to the GE Junction."

Medscape: "Esophageal Cancer."

NHS: "Living with oesophageal cancer."

Radiation Oncology : "Clinical management of gastroesophageal junction tumors: past and recent evidences for the role of radiotherapy in the multidisciplinary approach."

Reviewed by Laura J. Martin on November 06, 2017

SOURCES:

American Cancer Society: "Key Statistics for Esophageal Cancer," "Living as an Esophagus Cancer Survivor," "Radiation Therapy for Esophageal Cancer," "Surgery for Esophageal Cancer," "Targeted Therapy for Esophageal Cancer," "Tests for Esophageal Cancer," "What is Cancer of the Esophagus?"

Annals of Thoracic Surgery : "The Society of Thoracic Surgeons guidelines on the diagnosis and staging of patients with esophageal cancer."

Cancer.Net: "Esophageal Cancer: Questions to Ask the Doctor."

Cancer Research UK: "About gastro oesophageal junction cancer," "Survival," "Treatment for gastro oesophageal junction cancer."

Cleveland Clinic: "Esophageal Cancer."

Johns Hopkins Medicine: "The Migration of Gastric Cancer to the GE Junction."

Medscape: "Esophageal Cancer."

NHS: "Living with oesophageal cancer."

Radiation Oncology : "Clinical management of gastroesophageal junction tumors: past and recent evidences for the role of radiotherapy in the multidisciplinary approach."

Reviewed by Laura J. Martin on November 06, 2017

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