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What are targeted treatments for lung cancer?

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Scientists have learned that people with specific genetic combinations may benefit from targeted therapies like epidermal growth factor receptor blockers. Drugs such as afatinib (Gilotrif), erlotinib (Tarceva), gefitinib (Iressa), necitumumab (Portrazza) and Osimertinib (Tagrisso) block a signal that tells cells to grow.

The drugs alectinib (Alecensa), brigatinib (Alunbrig), certinib (Zykadia), and crizotinib (Xalkori) have been found to help treat certain cancers with a change in the ALK gene. Some of these drugs are also used to treat tumors with an ROS1 gene change. Dabrafenib (Tafinlar) and Trametinib (Mekinist) target certain proteins in tumors that have changes in the BRAF gene.

SOURCES:

American Cancer Society: “Key statistics for lung cancer,” “Can non-small cell lung cancer be found early?” “What’s new in non-small cell lung cancer research?” “Targeted therapy drugs for non-small cell lung cancer.”

U.S. Preventive Services Task Force: “Lung Cancer Screening.” Cancer Research Institute: “Lung Cancer.” Lung Cancer Alliance: “New Directions in Lung Cancer.”



Reviewed by Laura J. Martin on May 20, 2018

SOURCES:

American Cancer Society: “Key statistics for lung cancer,” “Can non-small cell lung cancer be found early?” “What’s new in non-small cell lung cancer research?” “Targeted therapy drugs for non-small cell lung cancer.”

U.S. Preventive Services Task Force: “Lung Cancer Screening.” Cancer Research Institute: “Lung Cancer.” Lung Cancer Alliance: “New Directions in Lung Cancer.”



Reviewed by Laura J. Martin on May 20, 2018

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