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What causes gastrointestinal-stromal tumors?

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Most cases of GIST have no clear cause and in rare cases are caused by an inherited gene mutation. In these rare cases, the mutation is in a gene that directs the cells to make a protein (called KIT or CD117) that causes the cells to grow and divide. In this case, the gene mutation causes the cells of Cajal to grow and divide in an uncontrolled manner, leading to a tumor.

Risk factors for GIST include certain inherited gene mutations.

SOURCES:

GSI. GIST Support International.

Demetri, G. Journal of the National Comprehensive Cancer Network. Published online July 6, 2007.

Demetri, G. Journal of the National Comprehensive Cancer Network. (Update to above). Published 2010.

American Cancer Society.

American Society of Clinical Oncology.

U.S. Food and Drug Administration. Gleevec Prescribing Information.  

News release, FDA.

Reviewed by Kumar Shital on July 18, 2020

SOURCES:

GSI. GIST Support International.

Demetri, G. Journal of the National Comprehensive Cancer Network. Published online July 6, 2007.

Demetri, G. Journal of the National Comprehensive Cancer Network. (Update to above). Published 2010.

American Cancer Society.

American Society of Clinical Oncology.

U.S. Food and Drug Administration. Gleevec Prescribing Information.  

News release, FDA.

Reviewed by Kumar Shital on July 18, 2020

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What is mutation testing for gastrointestinal-stromal tumors?

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