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What causes myelofibrosis (MF)?

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A problem with one of your genes causes you to make stem cells that don’t work the way they should. These are the cells that make blood in your bone marrow. With myelofibrosis (MF), they get inflamed, and scar tissue forms.

About 90% of people who get this kind of cancer have a change in one of three genes: JAK2, CALR, or MPL. These genes change during your lifetime, but we don’t know why. Maybe you were exposed to toxic chemicals or radiation. In most cases, you don’t inherit these gene problems from your parents, and you don’t pass them on to your children.

These faulty genes make copies of themselves. The bad versions spread through your marrow and try to stop your body from making normal blood cells.

We don’t know how to prevent MF, but there’s research under way to find out more about it.

SOURCES:

Leukemia and Lymphoma Society: “Myelofibrosis.”

Myeloproliferative Research Foundation: “Primary Myelofibrosis.”

National Organization for Rare Disorders: “Primary Myelofibrosis.”

American Cancer Society: “Find Support & Treatment.”

Reviewed by Brunilda Nazario on October 30, 2020

SOURCES:

Leukemia and Lymphoma Society: “Myelofibrosis.”

Myeloproliferative Research Foundation: “Primary Myelofibrosis.”

National Organization for Rare Disorders: “Primary Myelofibrosis.”

American Cancer Society: “Find Support & Treatment.”

Reviewed by Brunilda Nazario on October 30, 2020

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Who gets myelofibrosis (MF)?

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