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Are there other treatments for a gastrointestinal-stromal tumor if I can't take Imatinib (Gleevec) or if it stops working?

ANSWER

Another drug called sunitinib (Sutent) is available. The drugs regorafenib (Stivarga) or ripretinib (Qinlock) may be used to treat patients with tumors that can't be surgically removed and no longer respond to Gleevec or Sutent.

Other drugs such as dasatinib (Sprycel), nilotinib (Tasigna), and sorafenib (Nexavar) are currently under study. Chemotherapy and radiation aren't effective treatments for gastrointestinal-stromal tumors.

SOURCES:

GSI. GIST Support International.

Demetri, G. Journal of the National Comprehensive Cancer Network. Published online July 6, 2007.

Demetri, G. Journal of the National Comprehensive Cancer Network. (Update to above). Published 2010.

American Cancer Society.

American Society of Clinical Oncology.

U.S. Food and Drug Administration. Gleevec Prescribing Information.  

News release, FDA.

Reviewed by Kumar Shital on July 18, 2020

SOURCES:

GSI. GIST Support International.

Demetri, G. Journal of the National Comprehensive Cancer Network. Published online July 6, 2007.

Demetri, G. Journal of the National Comprehensive Cancer Network. (Update to above). Published 2010.

American Cancer Society.

American Society of Clinical Oncology.

U.S. Food and Drug Administration. Gleevec Prescribing Information.  

News release, FDA.

Reviewed by Kumar Shital on July 18, 2020

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Will my gastrointestinal-stromal tumor cancer return after treatment?

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