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What other treatment options are available for a gastrointestinal-stromal tumor if Imatinib (Gleevec) can't be used?

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If you can’t take Gleevec for a gastrointestinal-stromal tumor or become resistant to it over time, another drug called sunitinib (Sutent) is available. The drug regorafenib (Stivarga) is used to treat patients who have tumors that cannot be surgically removed and no longer respond to Gleevec or Sutent.

Other drugs such as sorafenib (Nexavar), dasatinib (Sprycel), and nilotinib (Tasigna) are currently under study. Research has found that chemotherapy and radiation are not effective in the treatment of gastrointestinal-stromal tumors.

From: GIST: Frequently Asked Questions WebMD Medical Reference

SOURCES:

GSI. GIST Support International.

Demetri, G. . Published online July 6, 2007. Journal of the National Comprehensive Cancer Network

Demetri, G. . (Update to above). Published 2010. Journal of the National Comprehensive Cancer Network

American Cancer Society.

American Society of Clinical Oncology.

U.S. Food and Drug Administration. Gleevec Prescribing Information.  

News release, FDA.

Reviewed by Laura J. Martin on July 11, 2018

SOURCES:

GSI. GIST Support International.

Demetri, G. . Published online July 6, 2007. Journal of the National Comprehensive Cancer Network

Demetri, G. . (Update to above). Published 2010. Journal of the National Comprehensive Cancer Network

American Cancer Society.

American Society of Clinical Oncology.

U.S. Food and Drug Administration. Gleevec Prescribing Information.  

News release, FDA.

Reviewed by Laura J. Martin on July 11, 2018

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