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Which genes cause myelofibrosis and are they inherited?

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About 90% of people who get myelofibrosis have a change in one of three genes: JAK2, CALR, or MPL. These genes change during your lifetime, but scientists don’t know why. Maybe you were exposed to toxic chemicals or radiation. In most cases, you don’t inherit these gene problems from your parents, and you don’t pass them on to your children.

From: What Is Myelofibrosis? WebMD Medical Reference

SOURCES:

Leukemia and Lymphoma Society: “Myelofibrosis.”

Myeloproliferative Research Foundation: “Primary Myelofibrosis.”

National Organization for Rare Disorders: “Primary Myelofibrosis.”

American Cancer Society: “Find Support & Treatment.”

Reviewed by Michael W. Smith on December 26, 2017

SOURCES:

Leukemia and Lymphoma Society: “Myelofibrosis.”

Myeloproliferative Research Foundation: “Primary Myelofibrosis.”

National Organization for Rare Disorders: “Primary Myelofibrosis.”

American Cancer Society: “Find Support & Treatment.”

Reviewed by Michael W. Smith on December 26, 2017

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