bone cancer in knee
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What Is It?

It starts when a tumor forms in a bone. It usually begins in one of the long ones in your arm or leg. As it grows, it kills normal bone cells and may spread to other parts of your body. Bone cancer is most common in children and young adults.

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type of bone cancer
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Common Types

Osteosarcoma, the most common bone cancer, usually happens to people ages 10 to 30 and most often starts in the arms, legs, or pelvis. Ewing sarcoma also is more likely to be in kids and young adults. It starts most often in the arms, chest, legs, pelvis, and spine. People over 40 are more likely to have chondrosarcoma -- usually in the arms, legs, or pelvis. Cancers like leukemia that start in marrow -- tissue in some of your bones -- aren’t seen as bone cancer.

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types of rare bone cancer
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Rare Types

Other less common bone cancers tend to affect adults. These include giant cell tumors -- which usually happen around the knees in young adults -- and chordoma, which typically starts in the base of the skull or the tailbone. Fibrosarcoma is sometimes seen in older adults who have had radiation therapy for another kind of cancer. It’s typically found in the knees, hips, and jaw.

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What Can Raise Your Odds of Getting It?

Your chances of getting one of these cancers are higher if you have a bone disorder called Paget’s disease. And cancer treatment, like high doses of radiation and some cancer drugs, may make you more likely to have it, too. It happens more often in children and young adults whose bones are still growing. But with chondrosarcoma, it’s the reverse -- your odds go up as you get older.

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retinoblastoma in child's eye
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Health Conditions

You also may be more likely to get bone cancer if you have certain conditions caused by problem genes. These include a kind of eye cancer called hereditary retinoblastoma, Li-Fraumeni syndrome, and Rothmund-Thomson syndrome. And babies born with an umbilical hernia -- when part of an intestine or some tissue pokes through a weak spot in their belly -- are more likely to get Ewing sarcoma. But the chances of that are very low.

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Symptom: Pain

This is the most common early sign. It may come on slowly, starting out as tenderness you feel now and then, and become an ache that doesn’t go away. But this kind of pain can be caused by many things besides cancer, like growing pains and arthritis. See your doctor to find out what’s going on.

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teen with broken wrist
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Other Symptoms

You also may have:

  • Broken bones (the tumor can make your bone weak, and it may break more easily)
  • A lump over one of your bones 
  • Night sweats
  • Swelling and redness over a bone
  • Tiredness
  • Weight loss for no reason
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bone scan
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Diagnosis: Imaging Tests

Your doctor may recommend X-rays along with one or more of these to see if you have a tumor:

  • Bone scans: Your doctor puts a small amount of a radioactive substance in a vein in your arm, then uses a special camera to take pictures of your bones.
  • Computerized tomography (CT) scan: X-rays taken from different angles are put together to show the size and shape of a tumor and if it’s spread.
  • Magnetic resonance imaging (MRI) scan: Strong magnets and radio waves are used to clearly show the outline of a tumor.
  • Positron emission tomography (PET) scan: Radiation is used to make 3-D color images to check your body for cancer.
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bone biopsy
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Diagnosis: Biopsy

Your doctor takes out a small part of the tumor -- either through surgery or with a needle -- to test it for cancer cells. It’s the only way to know for sure if you have bone cancer.

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splitting cancer cells
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Imaging tests help your doctor figure out the stage of your cancer so they’ll know how to treat it:

  • Stage I hasn’t spread beyond the bone, and the cancer cells aren’t growing very quickly.
  • Stage II hasn’t spread, but cancer cells are growing quickly.
  • Stage III is in at least two places on the same bone.
  • Stage IV has spread beyond the bone.
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Treatment: Surgery

Your doctor’s recommendation will be based on the size, stage, and type of tumor, along with your overall health. Surgery to take out the tumor is the most common first step. To replace any bone that has to be taken out along with the tumor, your doctor may use bone from another part of your body or from a bone bank, or a metal implant.

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Treatment: Chemotherapy, Radiation

A combination of powerful drugs (chemotherapy) and beams of high-energy X-rays (radiation therapy) are sometimes used with surgery. They may help shrink a tumor beforehand or kill any cancer cells left afterward. Chemotherapy drugs travel throughout your body, so your doctor also may reccommend them if cancer has spread beyond the bone. And they may suggest radiation if surgery isn’t possible, or to help ease pain caused by advanced cancer.

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cryosurgery rods
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Treatment: Cryosurgery

During this type of surgery, your doctor puts a probe filled with liquid nitrogen right next to the tumor. The probe makes a ball of ice that freezes and destroys the cancer cells. This is usually used to treat bone cancers that aren’t growing quickly. In some cases, it also can help keep the joint from being damaged or help save an arm or a leg. 

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blood test
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Follow-Up Care

Bone cancer can spread to other parts of your body, including other bones, or it may come back in the same place. So you’ll have regular follow-up visits with your doctor, and they may want to do blood tests and X-rays to keep an eye on things. Depending on your treatment and where the cancer was, you also may need physical therapy to make parts of your body stronger and help you use them again.

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Sources | Medically Reviewed on 06/23/2019 Reviewed by Laura J. Martin, MD on June 23, 2019


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  2. Medical Images
  3. Getty Images, Science Source
  4. Thinkstock
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NHS: “Bone Cancer.”

Memorial Sloan Kettering Cancer Center: “Bone Cancer.”

National Institutes of Health, National Cancer Institute: “Bone Cancer,” “Cryosurgery in Cancer Treatment.”

American Cancer Society: “Bone Cancer.”

Mayo Clinic: “Bone Cancer.”

Reviewed by Laura J. Martin, MD on June 23, 2019

This tool does not provide medical advice. See additional information.

THIS TOOL DOES NOT PROVIDE MEDICAL ADVICE. It is intended for general informational purposes only and does not address individual circumstances. It is not a substitute for professional medical advice, diagnosis or treatment and should not be relied on to make decisions about your health. Never ignore professional medical advice in seeking treatment because of something you have read on the WebMD Site. If you think you may have a medical emergency, immediately call your doctor or dial 911.