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What causes fragile X syndrome?

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Fragile X syndrome happens because of genetic problems. The FMR1 gene normally makes a protein called FMR that helps nerve cells talk to one another. A child needs this protein for their brain to develop normally. Children with fragile X make too little or none of it. People with this condition also have more copies than usual of a DNA segment known as CGG. In most people, this segment repeats five to 40 times. In people with fragile X, it repeats more than 200 times. The more times this DNA segment repeats, the more serious the symptoms are.

From: Fragile X Syndrome WebMD Medical Reference

SOURCES:

CDC: "Facts about Fragile X Syndrome."

Cleveland Clinic: "Fragile X Syndrome."

Fraxa Research Foundation: "Are There Treatments for Fragile X Syndrome?" and "What Causes Fragile X Syndrome?"

March of Dimes: "Fragile X Syndrome."

National Fragile X Foundation: "Fragile X syndrome."

National Human Genome Research Institute: "Learning about Fragile X Syndrome."

U.S. National Library of Medicine: "Fragile X Syndrome."

Reviewed by Renee A. Alli on September 09, 2018

SOURCES:

CDC: "Facts about Fragile X Syndrome."

Cleveland Clinic: "Fragile X Syndrome."

Fraxa Research Foundation: "Are There Treatments for Fragile X Syndrome?" and "What Causes Fragile X Syndrome?"

March of Dimes: "Fragile X Syndrome."

National Fragile X Foundation: "Fragile X syndrome."

National Human Genome Research Institute: "Learning about Fragile X Syndrome."

U.S. National Library of Medicine: "Fragile X Syndrome."

Reviewed by Renee A. Alli on September 09, 2018

NEXT QUESTION:

Are boys or girls more likely to have fragile X syndrome?

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