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What causes inherited lipodystrophy?

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Researchers have found several genes that cause inherited lipodystrophy. That's why there are different subtypes. Sometimes, just one bad gene from one parent can cause it; sometimes, you must get a gene from each parent.

It’s also possible to have a bad gene without getting the disease.

From: Inherited Lipodystrophy WebMD Medical Reference

SOURCES:

NORD Physician Guides: "Lipodystrophy Disorders."

FDA: "FDA approves Myalept to treat rare metabolic disease."

Lipodystrophy United: "About Lipodystrophy."

University of Texas Southwestern Medical Center: "Lipodystrophy," "Lipodystrophy Therapies."

Genetics Home Reference: "Berardinelli-Seip congenital lipodystrophy."

KidsHealth: "Acanthosis Nigricans."

AACE Lipodystrophy Detection Consensus Statement, , January-February 2013. Endocrine Practice

Endocrine Society, Resource Room Slide Series: "Lipodystrophy: Metabolic and Clinical Aspects."

DermNet NZ: "Lipodystrophy."

Orphanet: "Berardinelli-Seip congenital lipodystrophy," "Familial partial lipodystrophy, Köbberling type," "Familial partial lipodystrophy, Dunnigan type," "Familial partial lipodystrophy associated with PPARG mutations."

Reviewed by Jennifer Robinson on February 2, 2019

SOURCES:

NORD Physician Guides: "Lipodystrophy Disorders."

FDA: "FDA approves Myalept to treat rare metabolic disease."

Lipodystrophy United: "About Lipodystrophy."

University of Texas Southwestern Medical Center: "Lipodystrophy," "Lipodystrophy Therapies."

Genetics Home Reference: "Berardinelli-Seip congenital lipodystrophy."

KidsHealth: "Acanthosis Nigricans."

AACE Lipodystrophy Detection Consensus Statement, , January-February 2013. Endocrine Practice

Endocrine Society, Resource Room Slide Series: "Lipodystrophy: Metabolic and Clinical Aspects."

DermNet NZ: "Lipodystrophy."

Orphanet: "Berardinelli-Seip congenital lipodystrophy," "Familial partial lipodystrophy, Köbberling type," "Familial partial lipodystrophy, Dunnigan type," "Familial partial lipodystrophy associated with PPARG mutations."

Reviewed by Jennifer Robinson on February 2, 2019

NEXT QUESTION:

What are the symptoms of congenital generalized lipodystrophy (CGL) in babies?

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