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Who is more likely to have urea cycle disorders (UCDs)?

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Parents pass these diseases down to their children through defective genes. We all inherit two copies of our genes, one from each parent. With most UCDs, you must get a defective gene from both parents to get the disease. The genes tell your child’s body how to break down protein.

One UCD, called ornithine transcarbamylase (OTC) deficiency, is what doctors call a sex-linked disorder. Mothers carry the gene on their X chromosome, and they mostly pass it to their sons.

From: What Are Urea Cycle Disorders? WebMD Medical Reference

SOURCES:

National Organization for Rare Disorders: “Ornithine Transcarbamylase Deficiency,” “Urea Cycle Disorders (UCD).”

Cincinnati Children’s: “Urea Cycle Disorder (UCD).”

Gene Reviews: “Urea Cycle Disorders Overview.”

National Organization for Rare Disorders: “Ornithine Transcarbamylase Deficiency.”

Reviewed by Hansa D. Bhargava on September 20, 2017

SOURCES:

National Organization for Rare Disorders: “Ornithine Transcarbamylase Deficiency,” “Urea Cycle Disorders (UCD).”

Cincinnati Children’s: “Urea Cycle Disorder (UCD).”

Gene Reviews: “Urea Cycle Disorders Overview.”

National Organization for Rare Disorders: “Ornithine Transcarbamylase Deficiency.”

Reviewed by Hansa D. Bhargava on September 20, 2017

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What are symptoms of complete urea cycle disorders (UCDs)?

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