Dr. Christopher P. Cannon: The PCS K9 inhibitors are a new kind of cholesterol lowering drug that are given every two weeks as injections, because they’re a monoclonal antibody that changes the way the body removes cholesterol. So interestingly, it prevents the breakdown of the receptors in the liver that take out the cholesterol so that you have more of them and it takes out more cholesterol. So a very interesting adaptation of the natural mechanism that we all have. Well, what’s been seen is that they can reduce cholesterol and the bad cholesterol in particular by 50% or more, and that’s on top of statin medications even at high doses. And so since high doses of statin reduced by 50% and you get another 50%, one can get cholesterol levels down to what we’re born with in the range of 30 and 40 milligrams per deciliter, so never seen before low levels. And so for people with very high levels and people who have had heart attacks and getting super low cholesterol levels, this is very exciting. But so far there have been no surprises or any big safety issues. Another question that comes up often is, can you have too low a cholesterol? And there, we haven’t seen that yet, but it remains a little bit of a question, because these drugs are so powerful you can get the cholesterol down to zero. And that seems like a probably not good idea, but we don’t know and we’re starting to evaluate patients who get the super duper low levels as to whether it is safe or not.