Coronavirus in Context: Lessons Learned from 5 Million Confirmed Cases

Published On Aug 10, 2020

Now that we've reached 5 million cases, our best hope to keep us from 10 million is a vaccine.Dealing with COVID is a marathon, not a sprint. We still have to be careful in how we behave.Our testing has improved and new testing is available, but we're not where we need to be.Large clinical trials for COVID vaccine candidates should reassure the public about their safety. 
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JOHN WHYTE
You're watching Coronavirus in Context. I'm Dr. John Whyte, Chief Medical Officer at WebMD. Today marks a serious milestone. Five million confirmed cases here in the United States. To put that in perspective, that's more people than are in the city of Los Angeles.

To help provide some insights, and also to give us guidance as to how we don't reach another five million confirmed cases, I've asked a frequent guest to return, Dr. William Schaffner. He's Professor of Preventive Medicine and Professor of Medicine in Infectious Disease at Vanderbilt University. Dr. Schaffner, thanks for joining me again.

WILLIAM SCHAFFNER
Good to be with you John, always, even on this sad occasion.

JOHN WHYTE
Yeah. Five million cases. Five million confirmed cases. Because we know we're at more than five million cases in the United States. What's the significance of this milestone?

WILLIAM SCHAFFNER
Well, it certainly is a testimony as to how small we are in the world. This is a virus that appeared on the scene as a human pathogen just a few months ago. It's spread all around the world. I think it's hit every continent on the globe, except maybe Antarctica.

And it's caused an enormous amount of illness, and, of course, many, many deaths. A huge amount of medical care resources have been devoted to this infection all around the world. It's-- it's halted economies. It's halted travel. It's had profound social and economic effects. It's-- it's enormous.

JOHN WHYTE
What's your guess in terms of how many cases we actually have here in the United States? As I mentioned, we know it's not at five million. That's five million confirmed cases. People who had tested, came back positive, and reported. Do you think it's 30 million, 40 million? Wh-- what's your best guess?

WILLIAM SCHAFFNER
Uh, I-- I don't have a real best guess. But it's some multiple of five million, that's for sure.

JOHN WHYTE
Yeah. And Dr. Schaffner, how do we make sure we don't get to another five million confirmed cases? As you've talked about, we're not on the right place on the curve. So I hope we're not talking to you in-- in three months and we're at 10 million confirmed cases.

WILLIAM SCHAFFNER
Well, John, you're-- you're-- you're asking me what my best hope for that is. And, of course, my best hope is for a vaccine. A vaccine that's safe and effective, and for which we can create a delivery mechanism that efficient, clear, transparent, and equitable, getting to all of the populations here in the United States and then beyond that around the world that are affected by this virus.

JOHN WHYTE
Are you more optimistic today than when we talked, you know, a few weeks ago and even a few months ago, about the availability of a vaccine next year?

WILLIAM SCHAFFNER
I'm more optimistic about a vaccine, that's for sure. Because we have several candidates that are in trials. And I think we'll get those results. And the early results are indeed encouraging, I would say.

One of the things that doesn't make me optimistic is that the behavioral interventions, all the social distancing, the mask wearing, and this-- and the like, hasn't gone nearly as rigorously in our country as I think it ought to have. And I think the public health leadership has been still put aside, and it's our political leaders that have led this campaign, and we should have left it to public health.

JOHN WHYTE
Do you think there is an element, though, of fatigue? You know, how long is this going to go on? How long do people have to wear masks? How long do we have to socially distance? So in many ways, people just have stopped doing it.

WILLIAM SCHAFFNER
Yeah, John. It's a marathon. It's not a sprint. And I think our population was not prepared. When we did lockdown, folks weren't told that once we opened up carefully, the carefully part would have to go on for a long time. That is the mask wearing and the social distancing.

Uh, I think our population was not prepared for that at all. And they have, as it were, thrown off the traces. Many of them, not everyone. But there is a lot of nonsocial distancing that's going on, if you will, or social nondistancing, I should say.

JOHN WHYTE
Are we fixing the issues of diagnostic testing in terms of the availability of the tests, getting the tests back sooner? As you know, that's been a big challenge. It doesn't help you have to wait seven to 10 days or longer to get back a test.

WILLIAM SCHAFFNER
John, that's been going on a step at a time. And yes, we are improving, but we're nowhere near where we ought to be. New tests are becoming available. We'll see if they're sufficiently rigorous, because some of them have the prospect, really, of providing very, very quick and, I hope, accurate results.

JOHN WHYTE
But remember when we talked early on with point of care testing? We had lots of challenges, both in diagnostic and antibody testing in terms of the accuracy and reliability of these tests. Have-- have we learned from our past mistakes in-- in addressing this pandemic?

WILLIAM SCHAFFNER
I-- I think we've learned lots of lessons. We haven't always been able to apply all of those lessons comprehensively across the country, I'm afraid.

JOHN WHYTE
I want to come back to the vaccine issue and the optimism towards vaccine. And for sake of argument, I'm going to say, OK, there is a vaccine early next year. But there's been a lot of studies, including one that we did recently on WebMD, that talked about a large percentage of people saying that they're not going to get the vaccine or they're not going to get the vaccine in the first couple of months.

It's this, I'm going to wait and see. I'm going to wait and see how you do, Dr. Schaffner, with the vaccine, and then I'm going to decide. Because it's these concerns, particularly about safety, um, when they feel something is being rushed. So how do we address that? Because there is a real concern that, just like masks have become, it's becoming politicized.

WILLIAM SCHAFFNER
Yeah. Well, we've made some mistakes. We've, uh, emphasized, I think, too much, how quickly we're moving. And what the general public, or many people in the general public are concerned about is that we're moving too quickly. That is, we're cutting corners.

We've tried to reassure people that we've not cut corners, and we will have to continue to do that. We'll have to be very transparent of exactly how effective the vaccines are. And they may differ in their effectiveness if we have several vaccines. We'll have to be very clear to which populations the vaccines are targeted and when, because we'll have to start with a priority list.

And as to safety, that will be very important. After all, these are new vaccines using new technologies against a new virus that's not really completely understood. So a degree of skepticism is appropriate.

JOHN WHYTE
Is seven to eight, nine months a sufficient amount of time to really determine safety?

WILLIAM SCHAFFNER
I think the large clinical trials, and they will be large, will provide a great deal of reassurance in that regard. And we'll have to transmit, communicate, our own degree of assurance and demonstrate that, as we and our families get the vaccine, that we think that this vaccine is safe for the average person in this country.

JOHN WHYTE
And-- and Dr. Schaffner, finally, what's your advice to viewers who are watching and simply just want to get back to their lives? What-- what do we tell them at this point?

WILLIAM SCHAFFNER
Tell them my heart is with them, but my brain says we have to keep up with the social distancing and the mask wearing for a while yet while we get ready for the vaccine.

JOHN WHYTE
What's been the most difficult part of this, um, public health strategies for you and your family?

WILLIAM SCHAFFNER
Well, for us, it's, uh, the remove from friends. We've wanted to get together, go out to dinner, have a little party at our house. But, uh, all of us with a little bit of gray hair have been very cautious about that. And we've gotten together with some family members. But even when we're together inside, we wear the masks and keep socially distancing. It's been a hug-free zone for us.

JOHN WHYTE
Dr. Schaffner, I want to thank you again for taking the time to share your insights. And, as you point out, hopefully we will not get to another five million confirmed cases. Thank you.

WILLIAM SCHAFFNER
Thanks, John.

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